1269233-01-3

Basic information

• Product Name: 2-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine
• Synonyms: 2-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine
• CAS NO: 1269233-01-3
• Molecular Weight: 253.536
• Mol File: 1269233-01-3.mol

Chemical Properties

• CAS DataBase Reference: 2-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine(1269233-01-3)
• EPA Substance Registry System: 2-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine(1269233-01-3)

Safety Data

• Hazardous Substances Data: 1269233-01-3(Hazardous Substances Data)

Upstream product

• 56131-46-5 3-bromo-2-chlorobenzenamine 
• 2622-14-2 tricyclohexylphosphine 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

PYRIDINE DERIVATIVES AS IMMUNOMODULATORS

Disclosed are pyridine derivatives of formula (I) and a pharmaceutical composition comprising the pyridine derivatives or their pharmaceutically acceptable salts or stereoisomers thereof, and at least one pharmaceutically acceptable carrier or excipient, which are useful as key intermediate for the synthesis of compounds to inhibit PD-1/PD-L1 signaling pathway or capable of inhibiting PD-1/PD-L1 signaling pathway.

Compound capable of being used as immunomodulator, and preparation method and application thereof

The invention relates to a micromolecular immunomodulator and discloses a method for preparing the micromolecular immunomodulator at the same time, and the micromolecular immunomodulator can be used for treating cancers or tumors, infectious diseases, metabolic diseases and other diseases and has great clinical value.

IMIDAZOPYRIMIDINE DERIVATIVES

The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS

The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

Compounds and Compositions as Protein Kinase Inhibitors

The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.