56131-46-5

Usage

Uses

Used in Dye Production:
3-bromo-2-chloroaniline is used as a key intermediate in the synthesis of various dyes due to its ability to impart color and stability to the dye molecules.
Used in Pharmaceutical Industry:
3-bromo-2-chloroaniline is used as a building block in the development of pharmaceutical compounds, particularly in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic applications.
Used in Agrochemical Industry:
3-bromo-2-chloroaniline is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, due to its potential to enhance the effectiveness and selectivity of these chemicals.
Used in Organic Synthesis:
3-bromo-2-chloroaniline is used as a versatile intermediate in organic synthesis, allowing for the creation of more complex molecules with diverse applications in various industries.
Used in Medicinal Chemistry:
3-bromo-2-chloroaniline is used as a promising candidate in medicinal chemistry for the development of new drugs and therapeutic agents, leveraging its unique chemical structure and reactivity.

Upstream product

• 121-18-6 3-nitro-4-chlorobenzenesulfonic acid 
• 59255-95-7 2-bromo-6-nitroaniline 
• 58534-94-4 2-fluoro-3-bromonitrobenzene 
• 863870-87-5 3 -bromo-2-chlorophenol 
• 1287791-79-0 N-(3-bromo-2-chlorophenyl)-2-hydroxy-2-methylpropanamide 
• 1287791-70-1 2-(3-bromo-2-chlorophenoxy)-2-methylpropanamide 
• 863870-81-9 O-3-bromo-2-chlorophenyl N,N-diethylcarbamate 
• 863870-72-8 O-3-bromophenyl N,N-diethylcarbamate 
• 3970-37-4 1-bromo-2-chloro-3-nitrobenzene 

Downstream Products

• 905438-50-8 3-bromo-2-chloro-N-cyclopropylaniline hydrochloride 
• 1269233-01-3 2-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine 
• 1269233-02-4 N-(3-bromo-2-chlorophenyl)propane-1-sulfonamide 
• 1304581-36-9 methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate 
• 1429790-80-6 7-bromo-8-chloroquinoline 

Relevant academic research and scientific papers

Preparation method 2 - chloro -3 - bromoaniline

The invention discloses a preparation method of 2 - chloro -3 - bromoaniline, and the specific steps of the preparation method are as follows: (1) the compound II and the bromosuccinimide are subjected to electrophilic substitution reaction to generate the compound III. (2) The sulfonic acid group of the compound III was removed to give compound IV. (3) Compound IV is reduced to compound I with a safety powder, i.e. said 2 - chloro -3 - bromoaniline. To the invention, 4 - chlorine -3 - nitrobenzene sulfonic acid is used as a starting raw material in a full synthetic route process, reagents with large toxicity and large pollution are avoided, and meanwhile, the raw materials are low in price and higher in yield.

PREPARATION AND APPLICATION OF CLASS OF N-CONTAINING HETEROCYCLIC COMPOUNDS HAVING IMMUNOREGULATORY FUNCTION

The present invention discloses the preparation and application of heterocyclic compound having immunoregulatory function. Specifically, the present invention discloses a compound having a structure according to Formula I, wherein the definition of each g

COUMARIN-LIKE CYCLIC COMPOUND AS MEK INHIBITOR AND USE THEREOF

Disclosed are a class of coumarin-like cyclic compounds as MEK inhibitors and pharmaceutical compositions comprising the compounds, and the use of same in the preparation of a drug for treating MEK-related diseases. Particularly disclosed are compounds as shown in formula (I) and pharmaceutically acceptable salts thereof or tautomers thereof.

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocycl

SUBSTITUTED QUINAZOLINE COMPOUNDS AND THEIR USE AS INHIBITORS OF G12C MUTANT KRAS, HRAS AND/OR NRAS PROTEINS

Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein R, R1, R2a, R2b, R2c, A, B, L1 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

Provided are certain pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP

INHIBITORS OF KRAS G12C

Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Compounds and Compositions as Protein Kinase Inhibitors

The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

FUSED PYRIMIDINE DERIVATIVE AND USES THEREOF

A compound represented by the formula (I) wherein ring A is a 5-membered aromatic heterocycle optionally having substituent(s), R1 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), W is an oxygen atom or a sulfur atom, X1 and X2 may be the same or different and each is a hydrogen atom, a hydrocarbon group optionally having substituent(s) or a heterocyclic group, or, X1 and X2 in combination optionally form an oxygen atom, a sulfur atom or =NR2, ring B is an aromatic ring optionally further having substituent(s), Y is a bond, C1-6 alkylene C2-6 alkenylene or C2-6 alkynylene, optionally having substituent(s), and Z is a group represented by formula: -SOnR3, or a group represented by formula: -COR4, or a salt thereof, is useful as a pharmaceutical agent having GnRH antagonistic action.