1269407-87-5

Upstream product

• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 1765-93-1 4-fluoroboronic acid 
• 1269407-86-4 1,1-dimethylethyl [(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]carbamate 

Downstream Products

• 1269408-82-3 (2S)-2-amino-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]butanamide hydrochloride 
• 1269408-83-4 (2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate 
• 1269408-84-5 N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-L-prolinamide hydrochloride 
• 1394001-74-1 1,1-dimethylethyl [4-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate 
• 1394001-73-0 1,1-dimethylethyl [1-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)cyclohexyl]carbamate 
• 1269407-90-0 1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-pyrrolidinecarboxylate 
• 1269407-88-6 1,1-dimethylethyl [(1S)-1-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)propyl]carbamate 
• 1269407-89-7 1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-azetidinecarboxylate 

Relevant academic research and scientific papers

CATHEPSIN C INHIBITORS

Disclosed are 3-aminopyrrolidines of Formula (I) having pharmacological activity, pharmaceutical compositions containing them, and methods for the treatment of diseases mediated by the cathepsin C enzyme such as chronic obstructive pulmonary disease

CATHEPSIN C INHIBITORS

Disclosed are 3-aminopyrrolidines of Formula (I) having pharmacological activity, pharmaceutical compositions containing them, and methods for the treatment of diseases mediated by the cathepsin C enzyme such as chronic obstructive pulmonary disease.