4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride

Base Information

Chemical Name:4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride
CAS No.:1269407-87-5
Molecular Formula:C₁₇H₁₆FN₃*ClH
Molecular Weight:317.793
Hs Code.:

Synonyms:4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride

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Chemical Property of 4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride

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Technology Process of 4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride

There total 3 articles about 4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269407-86-4
1,1-dimethylethyl [(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]carbamate

: 1269407-87-5
4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 179897-89-3
5-Bromo-2-fluoro-benzonitrile

: 1269407-87-5
4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1269407-87-5
4-[(3S)-3-amino-1-pyrrolidinyl]-4'-fluoro-3-biphenylcarbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;