1269421-40-0

Basic information

• Product Name: N-(3-amino-4-chloro-2-cyanophenyl)propane-1-sulfonamide
• Synonyms: N-(3-amino-4-chloro-2-cyanophenyl)propane-1-sulfonamide
• CAS NO: 1269421-40-0
• Molecular Weight: 273.743
• Mol File: 1269421-40-0.mol

Chemical Properties

• CAS DataBase Reference: N-(3-amino-4-chloro-2-cyanophenyl)propane-1-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-amino-4-chloro-2-cyanophenyl)propane-1-sulfonamide(1269421-40-0)
• EPA Substance Registry System: N-(3-amino-4-chloro-2-cyanophenyl)propane-1-sulfonamide(1269421-40-0)

Safety Data

• Hazardous Substances Data: 1269421-40-0(Hazardous Substances Data)

Upstream product

• 24243-71-8 propane-1-sulfonamide 
• 86225-73-2 3-chloro-2,6-difluorobenzonitrile 

Downstream Products

• 1396310-72-7 N-(4-chloro-2-cyano-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)propane-1-sulfonamide 
• 1269420-51-0 4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide 

Relevant articles and documents

HETEROCYCLIC SULFONAMIDES AS RAF INHIBITORS

Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I), stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.