1269429-08-4

Upstream product

• 1190391-61-7 (4S)-3-{(2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoyl}-4-phenyl-1,3-oxazolidin-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1190391-62-8 (2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid 
• 1190391-63-9 (R)-2-((S)-phenyl((trimethylsilyl)oxy)methyl)hex-5-ynoic acid 
• 1190391-88-8 (4R,5R)-2,2-dimethyl-4-(3-oxopropyl)-5-phenyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester 
• 1190391-87-7 tert-butyl (4R,5R)-2,2-dimethyl-4-[(1E)-3-oxoprop-1-en-1-yl]-5-phenyl-1,3-oxazolidine-3-carboxylate 
• 1269429-07-3 methyl 4-((5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-2-oxo-6-phenylhexyl)benzoate 
• 1269429-06-2 methyl 4-[3-((3R,4R)-3-{[(benzyloxy)carbonyl]amino}-4-{[tert-butyl(dimethyl)silyl]oxy}-4-phenylbutyl)oxiran-2-yl]benzoate 
• 1269429-04-0 methyl 4-((5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhex-1-en-1-yl)benzoate 
• 1269429-05-1 C₂₆H₃₇NO₃Si 
• 1269615-25-9 methyl 4-[(5R,6R)-5-amino-6-hydroxy-6-phenylhex-1-en-1-yl]benzoate hydrochloride 
• 1269429-02-8 tert-butyl (4R,5R)-4-{4-[4-(methoxycarbonyl)phenyl]but-3-en-1-yl}-2,2-dimethyl-5-phenyl-1,3-oxazolidine-3-carboxylate 

Downstream Products

• 1269429-09-5 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-5-[4-(methoxycarbonyl)benzyl]pyrrolidine-1-carboxylate 
• 1269615-33-9 tert-butyl (2R,5S)-2-[(R)-hydroxy(phenyl)methyl]-5-[4-({[(3-phenyl-1H-1,2,4-triazol-5-yl)methyl]amino}carbonyl)benzyl]pyrrolidine-1-carboxylate 
• 1269615-34-0 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-5-[4-[methyl(pyridine-3-ylmethyl)carbamoyl]benzyl]pyrrolidine-1-carboxylate 
• 1269615-41-9 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-5-(4-{[2-(pyridine-2-yl)ethyl]carbamoyl}benzyl)pyrrolidine-1-carboxylate 
• 1269615-42-0 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-5-(4-{methyl[2-(pyridine-2-yl)ethyl]carbamoyl}benzyl)pyrrolidine-1-carboxylate 
• 1269615-18-0 4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-[2-(pyridin-2-yl)ethyl]benzamide 
• 1269615-43-1 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-5-[4-(methylcarbamoyl)benzyl]pyrrolidine-1-carboxylate 
• 1269615-55-5 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-5-{4-[(2-fluorobenzyl)(methyl)carbamoyl]benzyl}pyrrolidine-1-carboxylate 
• 1269615-20-4 N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate 
• 1269615-54-4 tert-butyl (2R,5S)-2-(4-{[(6-bromopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate 
• 1269615-44-2 tert-butyl (2S,5R)-2-(4-{[(6-aminopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate 
• 1269429-10-8 C₂₅H₃₁NO₅ 
• 1269615-45-3 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-5-(4-{[1-(pyridine-2-yl)ethyl]carbamoyl}benzyl)pyrrolidine-1-carboxylate 
• 1269615-47-5 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-5-(4-{methyl[1-(pyridine-2-yl)ethyl]carbamoyl}benzyl)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder

The synthesis of a novel class of piperazine benzamide (reverse amides) targeting the human β3-adrenergic receptor for the treatment of overactive bladder (OAB) is described. The SAR studies directed towards maintaining well established β3 potency and selectivities while improving the overall pharmacokinetic profile in the reverse amide class will be evaluated. The results and consequences associated with functional activity at the norepinephrine transporter (NET) will also be discussed.

NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS

The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.