1269449-25-3

Basic information

• Product Name: 2,4-dichloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine,hydrochloride
• CAS NO: 1269449-25-3
• Molecular Weight: 0
• Mol File: 1269449-25-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-dichloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine,hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine,hydrochloride(1269449-25-3)
• EPA Substance Registry System: 2,4-dichloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine,hydrochloride(1269449-25-3)

Safety Data

• Hazardous Substances Data: 1269449-25-3(Hazardous Substances Data)

Downstream Products

• 1065114-27-3 tert-butyl 2,4-dichloro-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate 
• 635698-52-1 tert-butyl 2-chloro-4-(2,4-dichlorobenzylamino)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine-7-carboxylate 

Relevant articles and documents

BICYCLIC PYRIMIDINE DERIVATIVES

[wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m + n is 4 or less; R1 represents NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, -C(=O)-, -SO2-, -OC(=O)- or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like]ψBicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.