1269466-59-2Relevant academic research and scientific papers
Chemical synthesis of a heparan sulfate glycopeptide: Syndecan-1
Yang, Bo,Yoshida, Keisuke,Yin, Zhaojun,Dai, Hang,Kavunja, Herbert,El-Dakdouki, Mohammad H.,Sungsuwan, Suttipun,Dulaney, Steven B.,Huang, Xuefei
supporting information, p. 10185 - 10189,5 (2012/12/12)
Finishing first: The highly complex structure of the title compound (see picture) was assembled. The protective groups utilized, as well as the sequences for formation of the glycosyl linkages and protecting group removal are critical to the success of the synthesis. This first preparation of a heparan sulfate glycopeptide lays the foundation for accessing other members of this class of molecules. Copyright
One-pot strategies for the synthesis of the tetrasaccharide linkage region of proteoglycans
Huang, Teng-Yi,Zulueta, Medel Manuel L.,Hung, Shang-Cheng
supporting information; experimental part, p. 1506 - 1509 (2011/04/27)
A linker-attached tetrasaccharide corresponding to the linkage region of proteoglycans was synthesized via one-pot procedures from the silylated monosaccharide derivatives. Regioselective one-pot protection protocols were applied in generating the requisite monosaccharide building blocks whereas stereoselective one-pot glycosylation approaches were utilized to assemble the tetrasaccharide skeleton.
