1269515-86-7

Basic information

• Product Name: 2,6-difluoro-N-(2-methylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonamido)benzamide
• CAS NO: 1269515-86-7
• Molecular Weight: 409.416
• Mol File: 1269515-86-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,6-difluoro-N-(2-methylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonamido)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-difluoro-N-(2-methylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonamido)benzamide(1269515-86-7)
• EPA Substance Registry System: 2,6-difluoro-N-(2-methylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonamido)benzamide(1269515-86-7)

Safety Data

• Hazardous Substances Data: 1269515-86-7(Hazardous Substances Data)

Upstream product

• 80772-95-8 2-Methyl-6-nitro-pyrazolo[1,5-a]pyrimidine 
• 1103234-56-5 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid 
• 1018143-51-5 C₇H₈N₄ 

Relevant articles and documents

Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-RafV600E kinase with favorable physicochemical and pharmacokinetic properties

Herein we describe a novel series of ATP competitive B-Raf inhibitors based on the pyrazolo[1,5-a]pyrimidine scaffold. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. Optimization led to the identification of compound 17, a potent, selective and orally available agent with improved physicochemical and pharmacokinetic properties.