1269618-60-1Relevant articles and documents
Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin
Nicolaou,Jiang, Xuefeng,Lindsay-Scott, Peter J.,Corbu, Andrei,Yamashiro, Sawako,Bacconi, Andrea,Fowler, Velia M.
, p. 1139 - 1144 (2011)
Convergence and a biological dichotomy! Monorhizopodin (see structure) and its C16 epimer have been synthesized through a highly convergent strategy. Unlike the antitumor agent rhizopodin which is their naturally occurring dimer, monorhizopodin and its epimer exhibit potent inhibition of actin polymerization but no significant cytotoxicity.
An Effective Bifunctional Aldehyde Linchpin for Type II Anion Relay Chemistry: Development and Application to the Synthesis of a C16-C29 Fragment of Rhizopodin
Melillo, Bruno,Chen, Ming Z.,Forestieri, Roberto,Smith, Amos B.
supporting information, p. 6242 - 6245 (2016/01/09)
The design, synthesis, and validation of a new bifunctional aldehyde linchpin for Type II anion relay chemistry have been achieved. For this linchpin, the initial nucleophilic addition proceeds under Felkin-Anh control to generate the syn-alkoxide, which
