1269618-61-2Relevant academic research and scientific papers
Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin
Nicolaou,Jiang, Xuefeng,Lindsay-Scott, Peter J.,Corbu, Andrei,Yamashiro, Sawako,Bacconi, Andrea,Fowler, Velia M.
supporting information; experimental part, p. 1139 - 1144 (2011/04/18)
Convergence and a biological dichotomy! Monorhizopodin (see structure) and its C16 epimer have been synthesized through a highly convergent strategy. Unlike the antitumor agent rhizopodin which is their naturally occurring dimer, monorhizopodin and its epimer exhibit potent inhibition of actin polymerization but no significant cytotoxicity.
