1269627-60-2

Upstream product

• 92397-74-5 1-{[(2E)-4-oxo-4-phenylbut-2-enoyl]oxy}pyrrolidine-2,5-dione 
• 728925-59-5 N-[(2E)-4-(4-methoxyphenyl)-4-oxobut-2-enoyl]-L-leucine 
• 17812-07-6 Benzoylacrylic acid 
• 61-90-5 L-leucine 
• 1269627-48-6 N-[(2E)-4-oxo-4-phenylbut-2-enoyl]-L-leucine 
• 100-46-9 benzylamine 

Downstream Products

• 290298-02-1 N-[(2S)-2-amino-4-phenylbutanoyl]-L-leucine 
• 61-90-5 L-leucine 
• 943-73-7 D-homophenylalanine 
• 728925-59-5 N-[(2E)-4-(4-methoxyphenyl)-4-oxobut-2-enoyl]-L-leucine 
• 1269627-62-4 N-[(2R)-2-(benzylamino)-4-oxo-4-phenylbutanoyl]-L-leucine 

Relevant academic research and scientific papers

Crystallisation-induced asymmetric transformation (CIAT) for the synthesis of dipeptides containing homophenylalanine

A novel synthesis of highly enantioenriched dipeptides containing homophenylalanine is described. The process involves a crystallisation-induced asymmetric transformation (CIAT) in a Michael addition followed by exhaustive reduction. A unique example of a formally stereodivergent CIAT in conjugate addition of an achiral N-nucleophile to enantiomerically pure Michael acceptor has been discovered.