126963-90-4Relevant academic research and scientific papers
Wittig reactions of moderate ylides with heteroaryl substituents at the phosphorus atom
Ackermann, Marco,Berger, Stefan
, p. 6764 - 6771 (2005)
The influence of various heteroaryl substituents at the phosphorus atom to the stereoselectivity of Wittig reactions of allylic and benzylic ylides has been studied. In the case of nitrogen bearing heteroaromatic ligands at the phosphorous atom of benzylidenephosphoranes high E-alkene selectivity's of up to 90:10 could be observed. NMR spectroscopic investigations revealed that substituents at the phosphorus have influences on the reactivity of ylides as well as the stability of reaction intermediates. Indications for chelation of lithium ions with ylides could also be detected and will be discussed in this article.
Synthesis and characterization of alkyltris(2-pyridyl)phosphonium salts
Bowen, Richard J.,Fernandes, Manuel A.,Gitari, Patricia W.,Layh, Marcus
, p. 1403 - 1418 (2006)
Alkytris(2-pyridyl)phosphonium salts [(2-Py)3PR]X 1 [1a, R = Et, X = Br; 1b, R = Pr, X = Br; 1c, R = Bu, X = Br; 1d, R = CH2Ph, X = Br; 1e, R = CH2Ph, X = Cl] were synthesised from (2-Py)3P and an excess of RCl. 1c and 1e were found to rapidly decompose in hot acetone to 2,2′-bipyridinium(+1) bromide 2 and (2-Py)P(O)(CH2Ph)C(OH) Me2 3, respectively. A reaction mechanism for both products is proposed. All compounds were fully characterized, including X-ray crystallography for 1a and 3 with 1a being the first representative of this class of compounds characterized by this technique. Copyright Taylor & Francis Group, LLC.
Efficient One-Pot Synthesis of Mono- and Bis[di(2-pyridyl)phosphine Oxides] from Tris(2-pyridyl)phosphine
Malysheva, Svetlana F.,Gusarova, Nina K.,Belogorlova, Nataliya A.,Sutyrina, Anastasiya O.,Litvintsev, Yuriy I.,Albanov, Alexander I.,Sterkhova, Irina V.,Artem'ev, Alexander V.
supporting information, p. 2451 - 2454 (2016/10/24)
An efficient one-pot access to di(2-pyridyl)phosphine oxides Py2P(R)=O and bis[di(2-pyridyl)phosphine oxides] Py2P(O)-Z-P(O)Py has been developed based on the reaction of available tris(2-pyridyl)phosphine with various organic halides, followed by treatment of the resulting phosphonium salts with alkali in situ. The isolated yields of the phosphine oxides were in the range 40-96%.
