1269632-20-3Relevant academic research and scientific papers
Br?nsted Acid Catalyzed One-Pot Benzannulation of 2-Alkenylindoles under Aerial Oxidation: A Route to Carbazoles and Indolo[2,3- a]carbazole Alkaloids
Saha, Shuvendu,Banerjee, Ankush,Maji, Modhu Sudan
, p. 6920 - 6924 (2018)
A one-pot, protecting-group-free benzannulation of 2-alkenylindoles with readily available 1,3-dicarbonyls is demonstrated to construct structurally diverse carbazoles. The use of a cheap Br?nsted acid catalyst and air as the sole oxidant exemplifies the economic viability of this protocol. The execution of four different reactions successively to generate the medicinally important indolocarbazole core is also achieved. This one-pot protecting-group-free method paved the way for the total synthesis of three medicinally important alkaloids, namely staurosporinone, arcyriaflavin A, and 7-hydroxy-K252c.
Synthetic studies on indolocarbazoles: A facile synthesis of staurosporinone analogues
Raju, Potharaju,Gobi Rajeshwaran, Ganesan,Mohanakrishnan, Arasambattu K.
, p. 7131 - 7145 (2015/11/18)
Synthesis of indolocarbazoles was achieved through thermal electrocyclization followed by triethyl phosphite-mediated nitrene insertion reactions. Total synthesis of staurosporinone analogues was achieved from commercially available 2-methylindole. The CD
Synthetic studies on indolocarbazoles: Total synthesis of staurosporine aglycon
Rajeshwaran, Ganesan Gobi,Mohanakrishnan, Arasambattu K
supporting information; experimental part, p. 1418 - 1421 (2011/05/04)
A synthesis of staurosporine aglycon and its analogs was achieved in a 28-36% overall yield starting from 2-methylindole. The prominent key steps for the synthesis of the indolocarbazole alkaloids involved electrocyclization and nitrene insertion reactions.
