1269656-98-5Relevant academic research and scientific papers
A new class of urea-substituted cinchona alkaloids promote highly enantioselective nitroaldol reactions of trifluoromethylketones
Palacio, Carole,Connon, Stephen J.
, p. 1298 - 1301 (2011)
The first class of bifunctional cinchona-alkaloid catalysts incorporating a urea moiety at C-5′ has been developed. These materials catalyze the efficient and highly enantioselective 1,2-addition of nitromethane to trifluoromethylketones to form synthetically pliable products incorporating a quaternary stereocenter. Excellent product yields and levels of enantiomeric excess are possible, and the optimum catalyst structure is capable of promoting the Henry reaction involving alkyl trifluoromethylketones with unprecedented enantioselectivity.
