1269667-57-3

Basic information

• Product Name: 4-Chlorothieno[3,2-d]pyri...
• Synonyms: 4-Chlorothieno[3,2-d]pyriMidine-7-carboxylic acid
• CAS NO: 1269667-57-3
• Molecular Formula: C₇H₃ClN₂O₂S
• Molecular Weight: 214.63
• Mol File: 1269667-57-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chlorothieno[3,2-d]pyri...(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorothieno[3,2-d]pyri...(1269667-57-3)
• EPA Substance Registry System: 4-Chlorothieno[3,2-d]pyri...(1269667-57-3)

Safety Data

• Hazardous Substances Data: 1269667-57-3(Hazardous Substances Data)

Usage

General Description

4-Chlorothieno[3,2-d]pyrimidine is a chemical compound mostly used in the medical research field. It is a heterocyclic aromatic organic compound which is a colorless, crystalline solid. 4-Chlorothieno[3,2-d]pyri... is often used as a building block in pharmaceutical manufacturing for therapeutic drugs due to its biological activity. Some derivatives of this compound have been extensively studied for their anti-cancer properties as can intercalate or bind to DNA. Due to its significant role in life sciences, 4-Chlorothieno[3,2-d]pyrimidine is considered to be an essential ingredient in various medicinal chemistry protocols.

Upstream product

• 1318133-04-8 4-chlorothieno[3,2-d]pyrimidine-7-carbaldehyde 
• 1318133-02-6 (4-chlorothieno[3,2-d]pyrimidine-7-yl)methanol 
• 1318133-00-4 (4-chlorothieno[3,2-d]pyrimidine-7-yl)methyl acetate 
• 175137-21-0 4-chloro-7-methylthieno[3,2-d]pyrimidine 
• 175137-13-0 7-methyl-3,4-dihydrothieno[3,2-d]pyrimidin-4-one 
• 209286-57-7 7-(bromomethyl)-4-chlorothieno[3,2-d]pyrimidine 
• 85006-31-1 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester 
• 1246223-44-8 methyl 4-chlorothieno[3,2-d]pyrimidine-7-carboxylate 
• 1269667-38-0 methyl 4-hydroxythieno[3,2-d]pyrimidine-7-carboxylate 
• 31169-25-2 7-bromothieno[3,2-d]pyrimidine-4(3H)-one 
• 16234-10-9 3H-thieno[3,2-d]pyrimidin-4-one 

Downstream Products

• 1269666-21-8 4-aminothieno[3,2-d]pyrimidine-7-carboxylic acid [2-chloro-6-fluoro-3-(2-methylpropane-1-sulfonylamino)phenyl]amide 
• 1269667-60-8 4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1269666-22-9 4-aminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide 
• 1269666-24-1 4-aminothieno[3,2-d]pyrimidine-7-carboxylic acid (3-benzenesulfonylamino-2,6-difluoro-phenyl)amide 
• 1269667-61-9 4-chloro-N-(6-chloro-2-fluoro-3-(3-fluoropropylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1269666-26-3 4-aminothieno[3,2-d]pyrimidine-7-carboxylic acid [6-chloro-2-fluoro-3-(3-fluoro-propane-1-sulfonylamino)phenyl]amide 
• 1269666-82-1 4-methoxyaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide 
• 1269666-83-2 4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide 
• 1269667-24-4 thieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide 
• 1318133-08-2 N-(4-bromo-3,5-dimethoxyphenyl)-4-chlorothieno[3,2-d]pyrimidine-7-carboxamide 
• 1318133-05-9 4-chloro-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318133-07-1 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318128-97-0 4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318130-12-9 N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-chlorothieno[3,2-d]pyrimidine-7-carboxamide 

Relevant articles and documents

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES

The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.

Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties

Recent clinical data provided proof-of-concept for selective B-Raf inhibitors in treatment of B-RafV600E mutant melanoma. Pyrazolopyridine-type B-Raf inhibitors previously described by the authors are potent and selective but exhibit low solubility requiring the use of amorphous dispersion-based formulation for achieving efficacious drug exposures. Through structure-based design, we discovered a new class of highly potent aminopyrimidine-based B-Raf inhibitors with improved solubility and pharmacokinetic profiles. The hinge binding moiety possesses a basic center imparting high solubility at gastric pH, addressing the dissolution limitation observed with our previous series. In our search for an optimal linker-hinge binding moiety system, amide-linked thieno[3,2-d]pyrimidine analogues 32 and 35 (G945), molecules with desirable physicochemical properties, emerged as lead compounds with strong efficacy in a B-RafV600E mutant mouse xenograft model. Synthesis, SAR, lead selection, and evaluation of key compounds in animal studies will be described.

BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE

The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.