175137-21-0

Basic information

• Product Name: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE
• Synonyms: BUTTPARK 46\18-89;4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE;4-Chloro-7-methylthieno[2,3-d]pyrimidine;7-CHLORO-3-METHYLTHIENO(3,2-D)PYRIMIDINE;4-Chloro-7-methylthieno[3,2-d]pyrimidine 97%;4-Chloro-7-Methylthieno[3...;4-Chloro-7-methylthieno[3,2-d]pyrimidine97%
• CAS NO: 175137-21-0
• Molecular Formula: C₇H₅ClN₂S
• Molecular Weight: 184.65
• Mol File: 175137-21-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 124 °C
• Boiling Point: 301.3°C at 760 mmHg
• Flash Point: 136°C
• Appearance: /
• Density: 1.445g/cm³
• Vapor Pressure: 0.0019mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.78±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE(175137-21-0)
• EPA Substance Registry System: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE(175137-21-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 175137-21-0(Hazardous Substances Data)

Usage

Description

4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE is a heterocyclic organic compound characterized by the molecular formula C6H5ClN2S. It features a chlorine atom and a methyl group attached to a thiophene ring, fused with a pyrimidine ring. 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE is known for its versatile chemical properties and is primarily utilized in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE serves as an intermediate in the synthesis of various drugs and biologically active molecules. Its unique structure allows it to be a key component in the development of new pharmaceuticals, contributing to the advancement of medicinal chemistry.
Used in Research and Development:
In the realm of research and development, 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE is employed for the exploration and creation of new drugs and agrochemicals. Its presence in experimental settings aids in understanding its potential applications and interactions with other compounds.
Used in Organic Synthesis:
4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE also functions as a building block in organic synthesis, enabling the preparation of a wide array of organic compounds. Its structural attributes make it a valuable asset in the synthesis of complex organic molecules for various applications.

InChI:InChI=1/C7H5ClN2S/c1-4-2-11-6-5(4)9-3-10-7(6)8/h2-3H,1H3

Upstream product

• 443762-03-6 methyl 3-formamido-4-methylthiophene-2-carboxylate 
• 18678-13-2 2-methylthieno[3,2-d]pyrimidin-4-ol 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 85006-31-1 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester 
• 1246223-39-1 C₈H₈N₂S₂ 
• 175137-13-0 7-methyl-3,4-dihydrothieno[3,2-d]pyrimidin-4-one 

Downstream Products

• 209286-57-7 7-(bromomethyl)-4-chlorothieno[3,2-d]pyrimidine 
• 1269667-57-3 4-chlorothieno[3,2-d]pyrimidine-7-carboxylic acid 
• 1318133-05-9 4-chloro-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318133-07-1 4-amino-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318128-97-0 4-(cyclopropylamino)-N-(2,6-difluoro-3,5-dimethoxyphenyl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318133-08-2 N-(4-bromo-3,5-dimethoxyphenyl)-4-chlorothieno[3,2-d]pyrimidine-7-carboxamide 
• 1318130-12-9 N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-chlorothieno[3,2-d]pyrimidine-7-carboxamide 
• 1318131-14-4 N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446113-41-2 7-hydroxymethylthieno[3,2-d]pyrimidine 
• 871013-27-3 C₇H₅BrN₂S 
• 1414474-23-9 3-(5-{4-[(R)-3-(tert-butoxycarbonylaminomethyl)pyrrolidin-1-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)benzoic acid 
• 1414474-11-5 3-(5-{4-[(S)-3-(tert-butoxycarbonylaminomethyl)pyrrolidin-1-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)benzoic acid 
• 1414473-94-1 3-(5-{4-[(R)-2-(tert-butoxycarbonylaminomethyl)morpholin-4-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)benzoic acid 
• 1414473-81-6 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]-7-methylthieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-fluorobenzoic acid 

Relevant articles and documents

ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF

Provided herein are small molecule modulators of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)

A novel thienopyrimidinone analog was discovered as a potent and highly selective TAK1 inhibitor using the SBDD approach. TAK1 plays a key role in inflammatory and immune signaling, so TAK1 is considered to be an attractive molecular target for the treatm

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES

The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.