1269759-81-0

Basic information

• Product Name: (R)-benzyl tert-butyl (3-aminopropane-1,2-diyl)dicarbamate
• Synonyms: (R)-benzyl tert-butyl (3-aminopropane-1,2-diyl)dicarbamate
• CAS NO: 1269759-81-0
• Molecular Weight: 323.392
• Mol File: 1269759-81-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-benzyl tert-butyl (3-aminopropane-1,2-diyl)dicarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-benzyl tert-butyl (3-aminopropane-1,2-diyl)dicarbamate(1269759-81-0)
• EPA Substance Registry System: (R)-benzyl tert-butyl (3-aminopropane-1,2-diyl)dicarbamate(1269759-81-0)

Safety Data

• Hazardous Substances Data: 1269759-81-0(Hazardous Substances Data)

Upstream product

• 61040-22-0 N^β-benzyloxycarbonyl-N^α-Boc-(S)-β-aminoalanine methyl ester 
• 76387-70-7 (S)-3-amino-2-tert-butoxycarbonylaminopropionic acid 
• 65710-57-8 3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine 
• 7536-55-2 N-tert-butyloxycarbonylasparagine 
• 1269759-88-7 (S)-3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propyl methanesulfonate 
• 1269759-80-9 (S)-benzyl tert-butyl (3-azidopropane-1,2-diyl)dicarbamate 
• 721927-81-7 benzyl tert-butyl [(2S)-3-hydroxypropan-1,2-diyl]biscarbamate 

Downstream Products

• 1269759-83-2 C₂₂H₃₂ClN₃O₇ 
• 1269759-84-3 C₂₇H₃₇N₅O₉ 
• 1269759-85-4 C₂₅H₃₃N₅O₉ 
• 1269759-82-1 C₂₀H₃₁N₃O₆ 

Relevant articles and documents

Aminomethylene peptide nucleic acid (am -PNA): Synthesis, regio-/stereospecific DNA binding, and differential cell uptake of (α/γ, R / S) am- PNA analogues

Inherently chiral, cationic am-PNAs having pendant aminomethylene groups at α(R/S) or γ(S) sites on PNA backbone have been synthesized. The modified PNAs are shown to stabilize duplexes with complementary cDNA in a regio- and stereo-preferred manner with γ(S)-am PNA superior to α(R/S)-am PNAs and α(R)-am PNA better than the α(S) isomer. The enhanced stabilization of am-PNA:DNA duplexes is accompanied by a greater discrimination of mismatched bases. This seems to be a combined result of both electrostatic interactions and conformational preorganization of backbone favoring the cDNA binding. The am-PNAs are demonstrated to effectively traverse the cell membrane, localize in the nucleus of HeLa cells, and exhibit low toxicity to cells.