65710-57-8

Basic information

• Product Name: BOC-DAP(Z)-OH
• Synonyms: N-ALPHA-T-BUTOXYCARBONYL-N-BETA-CARBOBENZOXY-L-ALPHA, BETA-DIAMINOPROPIONIC ACID;BOC-DAP(Z)-OH;(S)-2-(N-BOC-AMINO)-3-(N-CBZ-AMINO)PROPIONIC ACID;(S)-2-[(tert-Butoxycarbonyl)amino]-3-(benzyloxycarbonylamino)propionic acid;Boc-Dap(Cbz)-OH;N-[(tert-Butoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-L-alanine;3-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)propanoate;N2-Boc-N3-Cbz-L-2,3-diaminopropionic acid
• CAS NO: 65710-57-8
• Molecular Formula: C₁₆H₂₂N₂O₆
• Molecular Weight: 338.36
• EINECS: 1533716-785-6
• Product Categories: Amino Acid Derivatives
• Mol File: 65710-57-8.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 548.7°C at 760 mmHg
• Flash Point: 285.6°C
• Appearance: /
• Density: 1.235
• Vapor Pressure: 7.12E-13mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: 2-8°C
• PKA: 3.68±0.10(Predicted)
• CAS DataBase Reference: BOC-DAP(Z)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-DAP(Z)-OH(65710-57-8)
• EPA Substance Registry System: BOC-DAP(Z)-OH(65710-57-8)

Safety Data

• Hazardous Substances Data: 65710-57-8(Hazardous Substances Data)

Usage

Uses

BOC-N3-CBZ-L-2,3-diaminopropionic Acid is a useful intermediate for organic synthesis.

InChI:InChI=1/C16H22N2O6/c1-16(2,3)24-15(22)18-12(13(19)20)9-17-14(21)23-10-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,17,21)(H,18,22)(H,19,20)/t12-/m0/s1

Upstream product

• 61040-22-0 N^β-benzyloxycarbonyl-N^α-Boc-(S)-β-aminoalanine methyl ester 
• 76387-70-7 (S)-3-amino-2-tert-butoxycarbonylaminopropionic acid 
• 1885-14-9 phenyl chloroformate 
• 7536-55-2 N-tert-butyloxycarbonylasparagine 
• 71749-02-5 N^β-Z-Dap-OMe*HCl 
• 65621-26-3 (S)-N,N'-dicarbobenzyloxy-2,3-diaminopropanoic acid 
• 659747-10-1 Boc₂-Asp(OBn)-OMe 
• 176755-21-8 N-bis-(tert-butoxycarbonyl)aspartic acid α-methyl ester 
• 80963-12-8 4-benzyl 1-methyl N-(tert-butoxycarbonyl)-L-aspartate 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 916426-80-7 4-azidocarbonylmethyl-5-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 
• 69875-20-3 (S)-3-(1,1-dimethylethoxy)carbonyl-5-oxo-4-oxazolidineacetic acid 
• 901284-66-0 4-isocyanatomethyl-5-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 
• 916426-81-8 4-(benzyloxycarbonylamino-methyl)-5-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 65710-58-9 N^α-Boc,N^β-Z-Dap*DCHA 
• 870537-62-5 Boc-2,3-diaminopropionic acid(Z)-CH₂Cl 
• 870537-69-2 Boc-2,3-diaminopropionic acid(Z)-[2,3-diaminopropionic acid(Z)]-CH₂Cl 
• 957135-09-0 C₂₅H₃₅N₃O₇ 
• 1000290-79-8 H-2,3-diaminopropionic acid(Z)-CH₂Cl 
• 870537-65-8 Boc-Ala-2,3-diaminopropionic acid(Z)-CH₂Cl 
• 501022-66-8 6-benzyloxycarbonylaminomethyl-3,5-dimethyl-1,2-dihydropyrazine-2-one 
• 501022-63-5 3-(Z-aminomethyl)-5,6-dimethyl-1,2-dihydropyrazin-2-one 
• 501022-57-7 3,6-bis(benzyloxycarbonylaminomethyl)-5-methyl-1,2-dihydropyrazin-2-one 
• 214826-63-8 6-benzyl-3-benzyloxycarbonylaminomethyl-5-methyl-2(1H)-pyrazinone 
• 214826-48-9 Boc-Dap(Z)-Phe-CH₂Cl 

Relevant articles and documents

LINKING AMINO ACID SEQUENCES, MANUFACTURING METHOD THEREOF, AND USE THEREOF

This invention provides compositions comprising linked amino acid sequences, pharmaceutical compositions comprising linked amino acid sequences, and methods of making thereof. This invention also provides methods of delivering said compositions to subjects and methods of treating various disorders and diseases using the said compositions.

A short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced a new set of spectroscopic responses to the ds-DNA secondary structure

A novel pyrene-guanidiniocarbonyl-pyrrole dye, characterised by a short, rigid linker between the two chromophores, interacts strongly with ds-DNA but only negligibly with ds-RNA. Under neutral conditions the dye shows strong selectivity toward AT-DNA (with respect to GC-DNA). Binding is accompanied by a specific ICD band at 350 nm and fluorescence quenching for all DNAs/RNAs studied. At pH 5 the affinity of the dye is reversed, now favouring GC-DNA over AT-DNA. A strong emission increase for AT-DNA is observed but with quenching for GC-DNA.

2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS

The invention provides certain 2-pyridyl carboxamide-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.