126976-31-6Relevant articles and documents
Direct Electrochemical Defluorinative Carboxylation of gem-Difluoroalkenes with Carbon Dioxide
Xie, Shi-Liang,Gao, Xiao-Tong,Wu, Hai-Hong,Zhou, Feng,Zhou, Jian
, p. 8424 - 8429 (2020/11/03)
We report a facile and economical synthesis of α-fluoroacrylic acids via direct electrochemical defluorinative carboxylation of gem-difluoroalkenes with CO2. By using a platinum plate as the working cathode and a cheap nickel plate as the anode in a user-friendly undivided cell under constant current conditions, the reactions proceed smoothly under room temperature, without the use of expensive transition metal catalysts, ligands, external base or reductant, affording the desired adducts in up to 83% yield and 20:1 Z/E ratio, with good functional group tolerance. A cyclic voltammetry study was conducted and suggested a novel ECEC process.
Selective C-F bond carboxylation of: Gem -difluoroalkenes with CO2 by photoredox/palladium dual catalysis
Zhu, Chuan,Zhang, Yu-Feng,Liu, Ze-Yao,Zhou, Lu,Liu, Haidong,Feng, Chao
, p. 6721 - 6726 (2019/07/17)
The catalytic C-F bond carboxylation of organofluorines with CO2 gas remains a challenging problem in synthetic chemistry. Here, we describe a selective defluorinative carboxylation of gem-difluoroalkenes through photoredox/palladium dual catal
Stereospecific synthesis of tri- and tetrasubstituted α-fluoroacrylates by mizoroki-heck reaction
Rousée, Kevin,Bouillon, Jean-Philippe,Couve-Bonnaire, Samuel,Pannecoucke, Xavier
supporting information, p. 540 - 543 (2016/02/18)
Ligand-free, efficient, palladium-catalyzed Mizoroki-Heck reaction between methyl α-fluoroacrylate and arene or hetarene iodides is reported for the first time. The reaction is stereospecific and provides fair to quantitative yields of fluoroalkenes. The Mizoroki-Heck reaction starting from more hindered and usually reluctant trisubstituted acrylate, to access tetrasubstituted fluoroalkenes, is also reported. Finally, the use of a three-step synthesis sequence, including Mizoroki-Heck reaction, allows the synthesis of fluorinated analogues of therapeutic agents with high yield.