126984-55-2Relevant academic research and scientific papers
SILICA GEL-CATALYZED CYCLIZATIONS OF MIXED KETENE ACETALS
Schinzer, Dieter,Kalesse, Markus,Kabbara, Jazid
, p. 5241 - 5244 (1988)
Mixed ketene acetals of type 2 undergo smooth cyclization upon treatment with silica gel yielding diastereoselectively bicyclooctanones of type 3.Alternatively, the same result was obtained by exposure of the substrates to TiCl4 at low temperature.
