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1269920-14-0

ethyl 4-[1-(4-fluorobenzyl)-4,5-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1269920-14-0 Structure

  • Basic information

    1. Product Name: ethyl 4-[1-(4-fluorobenzyl)-4,5-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate
    2. Synonyms: ethyl 4-[1-(4-fluorobenzyl)-4,5-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate
    3. CAS NO:1269920-14-0
    4. Molecular Formula:
    5. Molecular Weight: 427.429
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1269920-14-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 4-[1-(4-fluorobenzyl)-4,5-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 4-[1-(4-fluorobenzyl)-4,5-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate(1269920-14-0)
    11. EPA Substance Registry System: ethyl 4-[1-(4-fluorobenzyl)-4,5-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate(1269920-14-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1269920-14-0(Hazardous Substances Data)

1269920-14-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1269920-14-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,9,9,2 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1269920-14:
(9*1)+(8*2)+(7*6)+(6*9)+(5*9)+(4*2)+(3*0)+(2*1)+(1*4)=180
180 % 10 = 0
So 1269920-14-0 is a valid CAS Registry Number.

1269920-14-0Relevant articles and documents

HIV-1 integrase strand-transfer inhibitors: Design, synthesis and molecular modeling investigation

De Luca, Laura,De Grazia, Sara,Ferro, Stefania,Gitto, Rosaria,Christ, Frauke,Debyser, Zeger,Chimirri, Alba

, p. 756 - 764 (2011/03/20)

This study is focused on a new series of benzylindole derivatives with various substituents at the benzene-fused ring, suggested by our 3D pharmacophore model developed for HIV-1 integrase inhibitors (INIs). All synthesized compounds proved to be active in the nanomolar range (6-35 nM) on the strand-transfer step (ST). In particular, derivative 4-[1-(4-fluorobenzyl)- 5,7-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid (8e), presenting the highest best-fit value on pharmacophore model, showed a potency comparable to that of clinical INSTIs GS 9137 (1) and MK-0518 (2). The binding mode of our molecules has been investigated using the recently published crystal structure of the complex of full-length integrase from the prototype foamy virus in complex with its cognate DNA (PFV-IN/DNA). The results highlighted the ability of derivative 8e to assume the same binding mode of MK-0518 and GS 9137.

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