2531-63-7

Usage

General Description

2,3-DIMETHOXY-6-NITRO-BENZALDEHYDE is a chemical compound with the molecular formula C9H9NO5. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2,3-DIMETHOXY-6-NITRO-BENZALDEHYDE is known for its aromatic and aldehyde properties, making it useful in organic synthesis. It is also used as a reagent in various chemical reactions, including the synthesis of 2,4-Dimethoxyphenethylamine. However, it is important to handle this chemical with care as it is known to be harmful if inhaled or ingested, and can cause irritation to the skin and eyes upon contact.

Upstream product

• 7697-37-2 nitric acid 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 64-19-7 acetic acid 
• 7461-60-1 2,3-dimethoxycinnamic acid 
• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 2426-86-0 2-hydroxy-3-methoxy-6-nitrobenzaldehyde 
• 103483-19-8 2-Hydroxy-3-methoxy-6-nitrobenzaldehyde potassium salt 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 2426-60-0 2-Hydroxy-3-methoxy-6-nitrobenzaldehyde benzenesulfonate 
• 2426-85-9 2-Hydroxy-3-methoxybenzaldehyde benzenesulfonate 
• 111042-36-5 2-Hydroxy-3-methoxy-6-nitrobenzaldehyde, sodium salt 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Downstream Products

• 72517-26-1 2,3-dimethoxy-6-nitrobenzoic acid 
• 5701-85-9 6-amino-2,3-dimethoxy-benzaldehyde 
• 98996-92-0 2,3-dimethoxy-6-nitro-benzyl alcohol 
• 109913-97-5 2,3-dimethoxy-6-nitro-benzaldehyde-oxime 
• 108711-22-4 6-Amino-2,3-dimethoxy-6-nitrobenzonitrile 
• 108711-21-3 2-nitro-5,6-dimethoxybenzonitrile 
• 92210-37-2 2,3-Dimethoxy-6-nitrobenzaldehyde ethylene acetal 
• 2426-86-0 2-hydroxy-3-methoxy-6-nitrobenzaldehyde 
• 1027150-95-3 (2,3-dimethoxy-6-nitro-phenyl)-(3,4,5-trimethoxy-phenyl)-methanol 
• 49635-16-7 5-methoxy-1H-indol-4-ol 
• 183005-89-2 2-acetoxy-3-methoxy-6-nitro-benzaldehyde 
• 92210-41-8 5,6-dimethoxy-2(1H)-quinazolinone 
• 92210-38-3 6-Amino-2,3-dimethoxybenzaldehyde ethylene acetal 
• 92210-40-7 6-(N-Carboethoxyamino)-2,3-dimethoxybenzaldehyde 

Relevant academic research and scientific papers

3-INDOLYL FURANOIDS AS INHIBITORS OF MATRIX METALLOPROTEINASE-9 FOR PREVENTION OF GASTRIC ULCER AND OTHER INFLAMMATORY DISEASES

Disclosed are 3-indolyl furanoid compounds which are useful as potent anti-inflammatory agents and prevent gastric ulcer by inhibiting matrix metalloproteinase-9 (MMP-9) expression in gastric mucosal layer. For example, disclosed is a compound of formula 1, wherein: R1 to R6 is selected from H, OH, CH3, OCH3, Br, Cl, Ph or o-OHC6H4, OCH2—CH═CH2, or OCH2CH2CH3, and R1 to R6 is having at least one substituent with alkyl, aryl and heteroaryl groups other than H, wherein the carbon in alkyl, aryl and heteroaryl is in the range of C1 to C8. Various embodiments relate to representative compounds of Formula 1 and method of preparation thereof. Further embodiments relates to the use of representative compounds of Formula 1 in treating diseases associated with gastric ulcer and other inflammatory diseases. A noted feature of an embodiment is the IC50 value of 50 μM of one of the 3-indolyl furanoids.

HIV-1 integrase strand-transfer inhibitors: Design, synthesis and molecular modeling investigation

This study is focused on a new series of benzylindole derivatives with various substituents at the benzene-fused ring, suggested by our 3D pharmacophore model developed for HIV-1 integrase inhibitors (INIs). All synthesized compounds proved to be active in the nanomolar range (6-35 nM) on the strand-transfer step (ST). In particular, derivative 4-[1-(4-fluorobenzyl)- 5,7-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid (8e), presenting the highest best-fit value on pharmacophore model, showed a potency comparable to that of clinical INSTIs GS 9137 (1) and MK-0518 (2). The binding mode of our molecules has been investigated using the recently published crystal structure of the complex of full-length integrase from the prototype foamy virus in complex with its cognate DNA (PFV-IN/DNA). The results highlighted the ability of derivative 8e to assume the same binding mode of MK-0518 and GS 9137.

Synthesis and adrenolytic activity of new propanolamines

The synthesis of (2R, S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)- 3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R, S)-1-(4-methoxy-6- (methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compound

Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2

The synthesis of (2RS)-1-(5-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2RS)-1-(7-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and its enantiomers, analogs of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol ((RS)-9) is described. Compounds were tested for electrographic, antiarrhythmic, hypotensive and spasmolytic activities as well as for α1-, α2- and β1-adrenoceptors binding affinities. The antagonist potency of the new compounds was compared with carvedilol and (RS)-9.

NEW DS DNA BINDING FLUORESCENT DYES

The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C

Antimicrobial indolequinones from the mid-intestinal gland of the muricid gastropod Drupella fragum

Three new indolequinones, 6-methoxyindole-4,7-quinone (1), 5- methoxyindole-4,7-quinone (2) and 5-methylindole-4,7-quinone (3) were isolated from the mid-intestinal gland of the muricid gastropod Drupella fragum. The structures of 1 and 2 were established

Process for preparing 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones

A method for preparing 5,6-dialkoxy-4-alkyl-quinazolinones is described. The 5,6-dialkoxy-4-alkyl-quinazolinones are active cardiotonic agents.

Substituted quinazolinediones

The synthesis of 5,6-dioxy substituted quinazolinediones is described. The novel quinazolinediones are useful as cardiotonic agents.

Process for the preparation of 8-halo-5,6-dialkoxyquinazoline-2,4-diones and their salts

A process for the preparation of 8-halo-5,6-dialkoxyquinazoline-2,4-diones and their metal salts is described. The diones are active cardiotonic agents.

Substituted 5,6-dialkoxyquinazoline derivatives

Quinazoline derivatives having an oxy substituent in 5 and 6 positions are described. The novel quinazoline derivatives are useful as cardiotonic agents.