126993-07-5

Upstream product

• 75-21-8 oxirane 
• 619-45-4 4-methoxycarbonyl aniline 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 141-43-5 ethanolamine 
• 624-76-0 Iodoethanol 
• 150-13-0 4-amino-benzoic acid 
• 619-44-3 methyl 4-iodobenzoate 

Downstream Products

• 121-92-6 3-nitrobenzoic acid 
• 117821-34-8 4-((2-hydroxyethyl)amino)benzoic acid 

Relevant academic research and scientific papers

Room-Temperature Practical Copper-Catalyzed Amination of Aryl Iodides

An efficient and highly practical procedure is reported for the Ullmann-Goldberg-type copper-catalyzed amination of aryl iodides. By using a combination of copper iodide and proline in the presence of an excess of an amine, a wide range of aryl iodides can be readily aminated at room temperature. The reaction proceeds well regardless of the electronic properties of the starting aryl iodide and the amination products can be obtained without the need for purification by column chromatography in most cases. Owing to its efficiency and the mildness of the reaction conditions, this amination could also be extended to the amination of complex aryl iodides at room temperature.

Development and validation of a docking-based virtual screening platform for the identification of new lactate dehydrogenase inhibitors

The human muscle isoform of lactate dehydrogenase (hLDH5) is one of the key enzymes of the glycolytic process. It is overexpressed in metastatic cancer cells and is linked to the vitality of tumors in hypoxic conditions. With the aim of identifying new hLDH5 inhibitors, a fully automated docking-based virtual screening platform was developed by considering different protein conformations and the consensus docking strategy. In order to verify the reliability of the reported platform, a small database of about 10,000 compounds was filtered by using this method, and the top-ranked compounds were tested for their hLDH5 inhibition activity. Enzymatic assays revealed that, among the ten selected compounds, two proved to efficiently inhibit enzyme activity with IC50 values in the micromolar range. These results demonstrate the validity of the methodologies we followed, encouraging the application of larger virtual screening studies and further refinements of the platform. Furthermore, the two active compounds herein described may be considered as interesting leads for the development of new and more efficient LDH inhibitors.

METHODS FOR PREPARING ANTIPROLIFERATIVE 5-SUBSTITUTED PYRIMIDONE COMPOUNDS

Intermediates for preparing derivatives of 5-thia- and5-selenopyrimidinone which are useful as inhibitors of the enzymes glydnamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). The present invention is also directed to methods of preparing these intermediates

Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds

The present invention is directed to derivatives of 5-thia- and 5-selenopyrimidinone, which are useful as inhibitors of the enzymes glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase AICARFT), pharmaceutical compositions containing these derivatives, and methods of using these derivatives. The present invention is also directed to intermediates useful for preparing these derivatives and methods of preparing these intermediates.