127-29-7 Usage
Description
An aconitine alkaloid obtained from A coniturn chasrnanthurn Stapf. by Dunstan
and Andrews, the base crystallizes from EtOH as hexagonal prisms or rosettes of
fine needles. It has [α]20Do + IS.3° (EtOH) and gives a series of crystalline salts,
e.g. the hydrobromide as hexagonal prisms from H20, m.p. lS3-7°C; [edo -
17.3° or as crystals from EtOH or Et 20, m.p. 217 -SoC and the aurichloride,
yellow needles, m.p. 147 -152°C with sintering at 142°C. Indaconitine resembles
Aconitine (q. v.) in giving a crystalline precipitate with KMn04 but in this case
the crystals are markedly smaller. Four methoxyl groups are present and when
the SUlphate is heated in aqueous solution in a sealed tube it furnishes acetic acid
and benzoylpseudaconine (Indbenzaconine), as a colourless glass, m.p. 130-3°C;
[α]D + 33.6° (EtOH), also giving crystalline salts: hydrochloride, m.p. 242-4°C;
[α]D - S.Oo (H 20); hydrobromide as the dihydrate, m.p. 247°C (dry) and the
aurichloride, rosettes of orange needles, m.p. 180-2°C.
Alkaline hydrolysis gives acetic and benzoic acids and pseudaconine,
C2sH4108N. On pyrolysis, the alkaloid loses one mole of acetic acid with the
formation of a-pyroindaconitine which is amorphous, m.p. 130-2°C; [α]D +
91.9° (EtOH), giving a crystalline hydro bromide, m.p. 194-SoC. When inda_x0002_conitine hydrochloride is subjected to the same treatment it yields the isomeric
~-pyroindaconitine, also amorphous, but furnishing a crystalline hydrobromide,
m.p. 24S-250°C; [α]D + 27.6°.
Chemical Properties
White crystalline, amorphous, or syrupy sub stance; salts are optically active; melts at214°C (417.2°F); insoluble in water, solublein alcohol, ether, and chloroform.
Uses
8-Acetyl ludaconitine occurs in the tubers of Indianaconite (bish or Aconitum ferox), found inIndia and Nepal. It is used in arrow poisoningfor hunting. Clinically, it is used in treatingrheumatism.
Health Hazard
Feraconitine is a highly toxic alkaloid. Theacute toxic effects are similar to those ofaconitine. The symptoms from ingestionare drowsiness, nervous disorders, weakness,.
References
Dunstan, Andrews, J. Chern. Soc., 87, 1620 (1905)
See also:
Bauer, Radjhan., Pharrn. Zent., 72,145 (1931)
Check Digit Verification of cas no
The CAS Registry Mumber 127-29-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 127-29:
(5*1)+(4*2)+(3*7)+(2*2)+(1*9)=47
47 % 10 = 7
So 127-29-7 is a valid CAS Registry Number.
InChI:InChI=1/C36H51NO12/c1-9-37-16-33(17-42-3)23(39)13-24(45-6)36-20-14-34(41)25(46-7)15-35(49-18(2)38,27(30(36)37)28(47-8)29(33)36)26(20)31(34)48-32(40)19-10-11-21(43-4)22(12-19)44-5/h10-12,20,23-31,39,41H,9,13-17H2,1-8H3
