1270004-62-0

Basic information

• Product Name: 4'-O-CO-Ala-[Asp(OtBu)-OtBu]-tricin
• Synonyms: 4'-O-CO-Ala-[Asp(OtBu)-OtBu]-tricin
• CAS NO: 1270004-62-0
• Molecular Weight: 672.686
• Mol File: 1270004-62-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-O-CO-Ala-[Asp(OtBu)-OtBu]-tricin(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-O-CO-Ala-[Asp(OtBu)-OtBu]-tricin(1270004-62-0)
• EPA Substance Registry System: 4'-O-CO-Ala-[Asp(OtBu)-OtBu]-tricin(1270004-62-0)

Safety Data

• Hazardous Substances Data: 1270004-62-0(Hazardous Substances Data)

Upstream product

• 108956-90-7 1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-ethan-1-one 
• 134178-07-7 methyl 4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethoxybenzoate 
• 520-32-1 5,7,4'trihydroxy-3',5'-dimethoxyflavone 
• 884-35-5 methyl syringate 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 13795-73-8 L-aspartic acid di-tert-butyl ester 
• 1270004-55-1 4'-O-CO-Ala-tricin 
• 1270004-49-3 4'-O-CO-(Ala-OtBu)-tricin 

Downstream Products

• 1270004-64-2 4'-O-CO-Ala-Asp-tricin 

Relevant articles and documents

Increased bioavailability of tricin-amino acid derivatives via a prodrug approach

Tricin (4′,5,7-trihydroxy-3′,5′-dimethoxyflavone) has demonstrated diverse biological activities. This compound has a high anti-human cytomegalovirus (HCMV) activity; however, its oral availability is low. To improve its bioavailability, we synthesized tricin-amino acid derivatives as prodrugs and investigated their cell permeability, stability in vitro, and oral availability in vivo. The results demonstrated that the tricin-alanine-glutamic acid conjugate exhibited enhanced permeability, stability in MDCK cells, and excellent bioavailability after oral administration in Crl:CD (SD) male rats. Tricin-alanine-glutamic acid conjugate is a potential new anti-HCMV drug.