134178-07-7

Upstream product

• 884-35-5 methyl syringate 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 520-32-1 5,7,4'trihydroxy-3',5'-dimethoxyflavone 
• 132018-15-6 3',5'-dimethoxy-4'-hydroxyflavone 
• 134178-10-2 2-(4-hydroxy-3,5-dimethoxyphenyl)-7-hydroxy-4H-benzopyran-4-one 
• 134178-09-9 2-(4-hydroxy-3,5-dimethoxyphenyl)-6-hydroxy-4H-benzopyran-4-one 
• 134178-08-8 2-(4-hydroxy-3,5-dimethoxyphenyl)-5-hydroxy-4H-benzopyran-4-one 
• 134178-11-3 7,8-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-benzopyran-4-one 
• 134178-18-0 7-acetoxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-benzopyran-4-one 
• 134178-15-7 2-<4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethoxyphenyl>-7-hydroxy-4H-benzopyran-4-one 
• 134178-14-6 2-<4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethoxyphenyl>-6-hydroxy-4H-benzopyran-4-one 
• 134178-16-8 2-<4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethoxyphenyl>-7,8-dihydroxy-4H-benzopyran-4-one 
• 134178-17-9 7-acetoxy-2-<4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethoxyphenyl>-4H-benzopyran-4-one 
• 1270004-47-1 4'-O-CO-Ala-Glu-tricin 
• 1270004-64-2 4'-O-CO-Ala-Asp-tricin 
• 1270004-63-1 4'-O-CO-Ala-[Glu(OtBu)-OtBu]-tricin 

Relevant academic research and scientific papers

Increased bioavailability of tricin-amino acid derivatives via a prodrug approach

Tricin (4′,5,7-trihydroxy-3′,5′-dimethoxyflavone) has demonstrated diverse biological activities. This compound has a high anti-human cytomegalovirus (HCMV) activity; however, its oral availability is low. To improve its bioavailability, we synthesized tricin-amino acid derivatives as prodrugs and investigated their cell permeability, stability in vitro, and oral availability in vivo. The results demonstrated that the tricin-alanine-glutamic acid conjugate exhibited enhanced permeability, stability in MDCK cells, and excellent bioavailability after oral administration in Crl:CD (SD) male rats. Tricin-alanine-glutamic acid conjugate is a potential new anti-HCMV drug.

A Short and Facile Synthetic Route to Hydroxylated Flavones. New Syntheses of Apigenin, Tricin, and Luteolin

Reaction of lithium polyanions generated from o-hydroxyacetophenones 3a-f with O-silyloxylated benzoates 2a-d gave 1-aryl-3-(2-hydroxyphenyl)-1,3-propanediones 4a-n, which on treatment with acetic acid containing 0.5percent H2SO4 at 95 - 100 deg C afforded hydroxylated flavones 5-18 in high yields (76 - 92percent).