127016-37-9

Upstream product

• 1066-54-2 trimethylsilylacetylene 
• 113964-33-3 (6-chlorohex-1-yn-1-yl)trimethylsilane 
• 94012-71-2 trimethyl(6-iodo-1-hexynyl)silane 
• 603-35-0 triphenylphosphine 

Downstream Products

• 1092444-49-9 tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate 
• 1092444-48-8 tert-butyl (R)-benzyl-{5-[1-(tert-butyl-dimethylsilyloxy)-9-(6-fluoropyridin-3-yl)-non-2-ylamino]-3-isopropyl-pyrazolo[1,5-a]pyrimidin-7-yl}carbamate 

Relevant academic research and scientific papers

Intramolecular Zinc-ene Reactions of Alkynes; Preparation of 1,5-Annulated 4-Methylenecyclopentenes

Intramolecular Type I zinc-ene reaction of 3-(alk-m-ynyl)-2-(methoxymethyl)-2-propenylzinc bromides 2 (m = 4,5,6) gave five-, six- and seven-membered carbometallation products 3, which on Pd(0)-catalyzed cyclization were converted to 1,5-annulated 4-methy

SELECTIVE INHIBITORS FOR CYCLIN-DEPENDENT KINASES

This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.