113964-33-3

Upstream product

• 10297-06-0 1-chloro-5-hexyne 
• 75-77-4 chloro-trimethyl-silane 
• 10297-05-9 1-chloro 4-iodobutane 
• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1092444-49-9 tert-butyl benzyl-((R)-5-(9-(6-fluoropyridin-3-yl)-1-hydroxynonan-2-ylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate 
• 1092444-48-8 tert-butyl (R)-benzyl-{5-[1-(tert-butyl-dimethylsilyloxy)-9-(6-fluoropyridin-3-yl)-non-2-ylamino]-3-isopropyl-pyrazolo[1,5-a]pyrimidin-7-yl}carbamate 
• 127016-37-9 triphenyl(6-(trimethylsilyl)-5-hexynyl)phosphonium iodide 
• 91656-99-4 (5-bromo-pent-1-ynyl)-trimehyl-silane 
• 144136-74-3 2-(4-chlorobutyl)-3-ethyl-4-(benzyloxymethyl)-1-(trimethylsilyl)-1,4-pentadiene 
• 144136-75-4 4-(benzyloxymethyl)-2-(4-chlorobutyl)-1-(trimethylsilyl)-1,4-heptadiene 
• 144115-81-1 <1-(2)H1>-4-(benzyloxymethyl)-2-(4-chlorobutyl)-1-(trimethylsilyl)-1,4-pentadiene 
• 113964-39-9 1-(4-chlorobutyl)-4-methylene-2-(trimethylsilyl)-1-cyclopentene 
• 1268810-13-4 2-cyclobutylethynyl(trimethyl)silane 

Relevant academic research and scientific papers

Intramolecular Metallo-Ene-Allene Reactions. A New Carbocycles Synthesis

Polysubstituted enynes have been lithiated on the propargylic position, and transmetalation to the corresponding zinc reagents promotes an easy cyclization reaction leading to polysubstituted cyclopentylmethylzinc derivatives.This cyclization is stereospecific, and a single diastereoisomer is formed, even when a tertiary and a quaternary center are linked in the process.The reaction is considered to take place via a metallo-ene-allene process.

1,5-ANNELATED 4-METHYLENECYCLOPENTENES BY INTRAMOLECULAR TYPE I ZINC-ENErREACTIONS FOLLOWED BY Pd(O)-CATALYZED CYCLIZATION.

3-/Alk-m-ynyl)-2-(methoxymethyl)-2-propenylzinc bromides 1 (m=4,5,6) undergo intramolecular carbometallation.The products 2 were converted by Pd(O)-catalyzed cyclization to 1,5-annelated 4-methylenecyclopentenes 3.

A Commercially Available and User-Friendly Catalyst for Hydroamination Reactions under Technical Conditions

The activity of a simple, commercially available copper salt, [Cu(NCMe)4](BF4) in intramolecular hydroamination reactions of alkynes and allenes is presented. Reactions were successfully carried out in technical acetonitrile in the presence of air. While attempts of alkene hydroamination failed, this catalyst was also found active in intermolecular aza-Michael reactions.

TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.

Regioselective Allylation of Carbon Electrophiles with Alkenyl-silanes under Dual Catalysis by Cationic Platinum(II) Species

In the presence of catalytic amounts of platinum(II) chloride and silver(I) hexafluoroantimonate, (Z)-alkenylsilanes reacted with various carbon electrophiles (acetals, aminals, carboxylic anhydrides, alkyl chlorides, etc.) at the γ-position to give allylation products. A plausible mechanism for the platinum-catalyzed allylation involves alkene migration of alkenylsilanes to allylsilanes and subsequent allylation of carbon electrophiles, both of which are catalyzed by a cationic platinum(II) species.

POLYCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Method for isolating or identifying a target protein interacting with a lipid in a cell

The invention is in the field of molecular biology and cell biology. It provides tools and methods for studying the interaction of proteins and lipids in vivo as well as in vitro. The invention relates to a method for isolating or identifying a target protein interacting with a lipid in a cell. This method employs novel dual-labeled lipid precursors such as fatty acids or their derivatives. These lipid precurors comprise two functional groups: a photoactivatable group, such as a diazirine ring, as well as a terminal alkyne or azide moiety.

Productive syntheses of 1-ethynylcyclopropylamine and 1- ethynylcyclobutylamine

The new 1,1-dimethylpropargylamine surrogates, 1-ethynylcyclopropylamine (3) and 1-ethynylcyclobutylamine (5), were prepared as hydrochlorides from cyclopropylacetylene and 6-chlorohex-1-yne in overall yields of 39 and 25%, respectively, on a scale of up to 300 mmol. The amine 3 was converted into the new ethynyl-extended 1-aminocyclopropanecarboxylic acid 4, and both the amine 3 as well as the amino acid 4 were made available as their N-Fmoc-protected derivatives. Georg Thieme Verlag Stuttgart - New York.