1270291-33-2Relevant academic research and scientific papers
Enantioselective addition of diethylzinc to aldehydes by chiral oxazolidine-titanium complex
Wu, Nan,Bo, Rongcheng,Zhang, Rongli,Jiang, Xi,Wan, Yu,Xu, Zhou,Wu, Hui
, p. 644 - 649 (2013/02/23)
A series of chiral oxazolidines derived from (1R, 2S)-cis-1-amino-2-indanol was found to be effective in promoting the asymmetric addition of diethylzinc to aldehydes. Among the ligands developed, it was found that ligand 1b in the presence of Ti(OiPr)4 yielded the highest enantioselectivities when it was applied in the catalytic asymmetric addition of diethylzinc to aldehydes (up to 91% ee).
L-proline-derived tertiary amino alcohols as chiral ligands for enantioselective addition of diethylzinc to aldehydes
Xu, Zhou,Bo, Rongcheng,Wu, Nan,Wan, Yu,Wu, Hui
experimental part, p. 582 - 586 (2012/05/31)
A series of L-proline derived tertiary amino alcohols was used as chiral ligands in the asymmetric addition reaction of Et2Zn to aldehydes. Among these ligands, it was found that ligand 1b which has the biggest steric and electrondonating substituent at the nitrogen position yielded the highest enantioselectivities when applied in the catalytic asymmetric addition of diethylzinc to p-chlorobenzadehyde. The experiment results of our paper may supply useful experience to help in revealing the relationship between ligand structure and ee values of the products.
