5779-93-1Relevant articles and documents
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Chollet,A. et al.
, p. 511 - 524 (1979)
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Method for preparing 2,3-dimethyl benzaldehyde
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Paragraph 0020; 00021, (2017/01/02)
The invention discloses a method for preparing 2,3-dimethyl benzaldehyde. The method includes the steps that firstly, under the protection of nitrogen, a Grignard reagent is prepared from 2,3-dimethyl benzene halide; secondly, the Grignard reagent and N,N-dimethyl formamide are reacted; finally, the 2,3-dimethyl benzaldehyde is prepared through hydrolyzing, purifying and separating. The method is reasonable in design, mild in reaction condition, simple in technology and easy and convenient to operate; the obtained 2,3-dimethyl benzaldehyde is a key intermediate for synthesizing dexmedetomidine hydrochloride, the sources of the raw materials are rich, and industrial applicability is achieved.
Formylation of electron-rich aromatic rings mediated by dichloromethyl methyl ether and TiCl4: Scope and limitations
Ramos-Tomillero, Iván,Paradís-Bas, Marta,De Pinho Ribeiro Moreira, Ibério,Bofill, Josep María,Nicolás, Ernesto,Albericio, Fernando
supporting information, p. 5409 - 5422 (2015/05/13)
Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regioselectivity of this process is highly promoted by the coordination between the atoms present in the aromatic moiety and those in the metal core.
