127033-39-0

Basic information

• Product Name: 4(1H)-Quinazolinone, 6,7-dimethoxy-2-[(1E)-2-phenylethenyl]-
• CAS NO: 127033-39-0
• Molecular Formula: C18H16N2O3
• Molecular Weight: 308.337
• Mol File: 127033-39-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinazolinone, 6,7-dimethoxy-2-[(1E)-2-phenylethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinazolinone, 6,7-dimethoxy-2-[(1E)-2-phenylethenyl]-(127033-39-0)
• EPA Substance Registry System: 4(1H)-Quinazolinone, 6,7-dimethoxy-2-[(1E)-2-phenylethenyl]-(127033-39-0)

Safety Data

• Hazardous Substances Data: 127033-39-0(Hazardous Substances Data)

Upstream product

• 35241-23-7 6,7-dimethoxy-2-methylquinazoline-4(3H)-one 
• 100-52-7 benzaldehyde 
• 6286-65-3 6,7-dimethoxy-2-methyl-4H-benzo[d] [1,3]oxazin-4-one 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 102-92-1 Cinnamoyl chloride 

Relevant articles and documents

Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1

The ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) was recently shown to promote mineralization of the aortic valve, hence, its inhibition represents a significant target. A quinazoline-4-piperidine sulfamide compound (QPS1) has been described as a specific and non-competitive inhibitor of NPP1. We report herein the synthesis and in vitro inhibition studies of novel quinazoline-4-piperidine sulfamide analogues using QPS1 as the lead compound. Of the 26 derivatives prepared, four compounds were found to have Ki 105 nM against human NPP1.