127034-04-2Relevant articles and documents
Synthesis and cytotoxic properties of nitro- and aminochalcones
Pati, Hari N.,Holt Jr., Herman L.,LeBlanc, Regan,Dickson, John,Stewart, Michelle,Brown, Toni,Lee, Moses
, p. 19 - 25 (2005)
Twenty-two nitro- and aminochalcones were synthesized and characterized. Their cytotoxic properties were determined by a 3-day continuous exposure MTT assay with murine melanoma B16 cells. The aminochalcones were generally more cytotoxic than their nitro
Chalcones: A new class of antimitotic agents
Edwards,Stemerick,Sunkara
, p. 1948 - 1954 (2007/10/02)
A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-propen- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa