127073-67-0

Basic information

• Product Name: methyl 2-((benzyl(cyanomethyl)amino)methyl)acrylate
• Synonyms: methyl 2-((benzyl(cyanomethyl)amino)methyl)acrylate
• CAS NO: 127073-67-0
• Molecular Weight: 244.293
• Mol File: 127073-67-0.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-((benzyl(cyanomethyl)amino)methyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-((benzyl(cyanomethyl)amino)methyl)acrylate(127073-67-0)
• EPA Substance Registry System: methyl 2-((benzyl(cyanomethyl)amino)methyl)acrylate(127073-67-0)

Safety Data

• Hazardous Substances Data: 127073-67-0(Hazardous Substances Data)

Upstream product

• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 107-14-2 chloroacetonitrile 
• 100-46-9 benzylamine 
• 3010-05-7 benzylaminoacetonitrile 

Downstream Products

• 127073-68-1 methyl 3-benzyl-6-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate 
• 127073-68-1 (1S,5S)-3-Benzyl-6-oxo-3-aza-bicyclo[3.3.1]nonane-1-carboxylic acid methyl ester 

Relevant articles and documents

TiCL4 INDUCED IMINIUM ION CYCLIZATIONS OF α-CYANOAMINES

Tertiary α-cyanoamines served as the precursors of iminium ions in the presence of titanium tetrachloride.Various intramolecular nucleophiles, olefinic and acetylenic, were found to produce cyclized products.The influences of ring sizes and substitutions on the double bonds were also investigated.

A tandem Diels-Alder/Mannich approach to the synthesis of AE and ABE ring analogues of Delphinium alkaloids

The one-pot TiCl4 catalysed Diels-Alder/Mannich reaction of α-cyanoaminoacrylates with 2-silyloxy-1,4-butadienes gives 6-keto-3-azabicyclo[3.3.1]nonane-1-carboxylates. Reduction of the ketone and alkylation of the resultant alcohol gives 6-alkoxy-3-azabicyclo[3.3.1]nonanes mimicking the AE rings of a number of Delphinium and Aconitum alkaloids, with the same stereochemistry as the natural products.