127073-80-7

Upstream product

• 127073-74-9 [Benzyl-(2,2-dimethyl-but-3-enyl)-amino]-acetonitrile 
• 86269-11-6 (Tributylstannyl)methyl methanesulfonate 
• 634180-67-9 (E)-N-benzyl-5-amino-2-methyl-1-methoxypent-2-ene 
• 98014-77-8 3-(N-benzyl-N-tert-butoxycarbonylamino)propanal 
• 198781-68-9 (E)-ethyl N-benzyl-N-tert-butoxycarbonyl-5-amino-2-methyl-2-pentenoate 
• 634180-63-5 (E)-N-benzyl-N-tert-butoxycarbonyl-5-amino-2-methylpent-2-en-1-ol 
• 634180-65-7 (E)-N-benzyl-N-tert-butoxycarbonyl-5-amino-2-methyl-1-methoxypent-2-ene 
• 198781-66-7 E-N-benzyl-N-tributylstannylmethyl-5-amino-2-methyl-1-methoxypent-2-ene 
• 127073-73-8 [Benzyl-(4-methyl-pent-3-enyl)-amino]-acetonitrile 

Relevant academic research and scientific papers

Intramolecular carbolithiation reactions for the preparation of 3-alkenylpyrrolidines.

Tin-lithium exchange allows the formation of alpha-amino-organolithium species that undergo anionic cyclization onto allylic ethers to give 3-alkenylpyrrolidines. The methodology has been applied to the synthesis of an advanced intermediate related to the natural product (-)-alpha-kainic acid.

Synthesis of pyrrolidines by anionic cyclization onto allylic ethers, alkynes and carboxylic groups

α-Amino-methylstannanes with pendent allylic ether, alkyne or carboxylic groups, can be converted, on treatment with butyllithium, to 3-vinyl-, 3-methylene- or 3-keto-pyrrolidines by anionic cyclization.

TiCL4 INDUCED IMINIUM ION CYCLIZATIONS OF α-CYANOAMINES

Tertiary α-cyanoamines served as the precursors of iminium ions in the presence of titanium tetrachloride.Various intramolecular nucleophiles, olefinic and acetylenic, were found to produce cyclized products.The influences of ring sizes and substitutions on the double bonds were also investigated.