198781-68-9Relevant academic research and scientific papers
Synthesis of pyrrolidines by anionic cyclization onto allylic ethers, alkynes and carboxylic groups
Coldham, Iain,Lang-Anderson, Maria M.S.,Rathmell, Richard E.,Snowden, David J.
, p. 7621 - 7624 (1997)
α-Amino-methylstannanes with pendent allylic ether, alkyne or carboxylic groups, can be converted, on treatment with butyllithium, to 3-vinyl-, 3-methylene- or 3-keto-pyrrolidines by anionic cyclization.
Intramolecular carbolithiation reactions for the preparation of 3-alkenylpyrrolidines.
Coldham, Iain,Price, Kathy N,Rathmell, Richard E
, p. 2111 - 2119 (2007/10/03)
Tin-lithium exchange allows the formation of alpha-amino-organolithium species that undergo anionic cyclization onto allylic ethers to give 3-alkenylpyrrolidines. The methodology has been applied to the synthesis of an advanced intermediate related to the natural product (-)-alpha-kainic acid.
