127075-07-4Relevant academic research and scientific papers
Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XI: Oligoamines with two primary amino groups
Rehse,Rose,Leissring
, p. 103 - 108 (2007/10/02)
Ten branched α,ω-alkanediamines with two primary amino groups have been synthesized and tested for their antiplatelet and anticoagulant effects. Seven of them inhibited the platelet aggregation induced by collagen at an IC50 ranging from 5-11 μmol/L. In concentrations up to 400 μmol/L the one stage thromboplastin time was only slightly prolonged (Δt 7s).
