1270942-77-2

Upstream product

• 6737-11-7 2-acetoxy-3-butene 
• 84695-30-7 (Z)-3-bromo-2-methylprop-2-ene-1-ol 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1270942-86-3 (3E,6S,7S,8R,9Z)-12-{2,5-dimethoxy-3-[(3R,4E)-3-methoxyhepta-4,6-dienamido]phe-nyl}-8-(4-methoxybenzyloxy)-7,9-dimethyldodeca-1,3,9-trien-6-yl1-[(cyclohex-1-ene)amido]cyclopropane-1-carboxylate 
• 1270942-87-4 C₄₇H₆₀N₂O₉ 
• 1270942-78-3 (3S,4R,5Z)-6-bromo-4-(4-methoxybenzyloxy)-3,5-dimethylhex-5-ene-1,2-diol 
• 1270942-88-5 4-[(2R,3R,4Z)-5-bromo-3-(4-methoxybenzyloxy)-4-methylpent-4-en-2-yl]-2,2-dime-thyl-1,3-dioxolane 
• 1270942-79-4 4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane 
• 1270942-80-7 (2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal 
• 1270942-81-8 (3E,6R,7S,8R,9Z)-12-(2,5-dimethoxy-3-nitrophenyl)-8-(4-methoxybenzyloxy)-7,9-dimethyldodeca-1,3,9-trien-6-ol 
• 1270942-82-9 (3E,6R,7S,8R,9Z)-12-(2,5-dimethoxy-3-nitrophenyl)-8-(4-methoxybenzyloxy)-7,9-dimethyldodeca-1,3,9-trien-6-yl 1-azidocyclopropane-1-carboxylate 
• 1270942-83-0 (3E,6R,7S,8R,9Z)-12-(2,5-dimethoxy-3-nitrophenyl)-8-(4-methoxybenzyloxy)-7,9-dimethyldodeca-1,3,9-trien-6-yl 1-aminocyclopropane-1-carboxylate 
• 1270942-85-2 (3E,6R,7S,8R,9Z)-12-(2,5-dimethoxy-3-nitrophenyl)-8-(4-methoxybenzyloxy)-7,9-dimethyldodeca-1,3,9-trien-6-yl 1-[(cyclohex-1-ene)amido]cyclopropane-1-carboxylate 

Relevant academic research and scientific papers

Synthesis of the cytotrienin A core via metal catalyzed C-C coupling

A synthetic approach to the C17-benzene ansamycins via metal catalyzed C-C coupling is described. Key bond formations include direct iridium catalyzed carbonyl crotylation from the alcohol oxidation level followed by chelation-controlled Sakurai-Seyferth dienylation to form the stereotriad, which is attached to the arene via Suzuki cross-coupling. The diene-containing carboxylic acid is prepared using rhodium catalyzed acetylene-aldehyde reductive C-C coupling mediated by gaseous hydrogen. Finally, ring-closing metathesis delivers the cytotrienin core.