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127103-11-1

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Product FOB Price Min.Order Supply Ability Supplier
Ac-Ser-Asp-Lys-Pro-OH
Cas No: 127103-11-1
No Data 1 Milligram 5 Xiamen Jenny Chemical Technology Co., Ltd. Contact Supplier
Factory Price API 99% AC-SER-ASP-LYS-PRO-OH 127103-11-1 GMP Manufacturer
Cas No: 127103-11-1
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
CAS 127103-11-1 AC-SER-ASP-LYS-PRO-OH
Cas No: 127103-11-1
USD $ 1000.0-1000.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
Acetyl-serinyl-aspartyl-lysinyl-proline
Cas No: 127103-11-1
No Data No Data No Data Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
acetyl-ser-asp-lys-pro
Cas No: 127103-11-1
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Seraspenide/ CAS:127103-11-1/ Raw material supply
Cas No: 127103-11-1
USD $ 1.0-2.0 / Kilogram 25 Kilogram 1 Metric Ton/Month Hubei DiBo chemical co., LTD Contact Supplier
High quality Thymosin beta 4 (1-4)
Cas No: 127103-11-1
No Data 10 Gram 1 Kilogram/Month Wuhan Wonda Pharm Limited Contact Supplier
L-Proline,N-acetyl-L-seryl-D-a-aspartyl-L-lysyl- (9CI)
Cas No: 127103-11-1
No Data No Data 5 Hangzhou J&H Chemical Co., Ltd. Contact Supplier
cas:127103-11-1
Cas No: 127103-11-1
No Data 10 Gram 500 Kilogram/Week Zibo Hangyu Import&Export Co., Ltd Contact Supplier
AC-SER-ASP-LYS-PRO-OH
Cas No: 127103-11-1
No Data 1 Kilogram 100 Kilogram/Day HANGZHOU CLAP TECHNOLOGY CO,.LTD Contact Supplier

127103-11-1 Usage

Skin Benifits

AcSDKP is an oligopeptide composed of acetyl-Ser-Asp-Lys-Pro. Found at low concentrations endogenously, AcSDKP is produced from thymosin and inhibits the phosphorylation of Smad2, therefore downsizing the expression of genes regulated by TGFβ. This mechanism mediates an antifibrotic effect and a reduction in edema. AcSDKP is catabolized almost exclusively by angiotensin converting enzyme I (ACEI), although ACEI-resistant analogs have been created. AcSDKP has been recognized as a potent inducer of angiogenesis and an anti-inflammatory agent, also contributing to its anti-fibrotic effects. Its cutaneous anti-aging effects have also been investigated. AcSDKP at a concentration of 10?7–10?11 stimulates the expression of proteins that strengthen tight junctions, including caludin-1, occluding, and ZO-1. In an ex vivo study, topical AcSDKP accelerated skin healing after UV irradiation. AcSDKP also stimulates the proliferation of keratinocytes, fibroblasts, and epidermal basal layer cells. Topical application of 10?5 M AcSDKP also inhibits aging of human skin explants by significantly increasing epidermal thickness after only six days, increases collagen III along the papillary dermis and collagen IV along the basal membrane, with a concomitant increase in GAGs, especially HA. This peptide also modulates the growth of human hair in an ex vivo study. Treatment of normal human dermal fibroblast cells with AcSDKP showed increased collagen I synthesis and SIRTI, improving skin structure and increasing cell longevity.78 In one study, topically administered AcSDKP on an ex vivo skin-explant model significantly increases epidermis thickness after only six days of treatment with 10?8 M AcSKDP. In addition to upregulating the expression of collagen and fibronectin along the dermo-epithelial junction, AcSKDP also increases GAG deposited in the ECM, especially hyaluronic acid. Lastly, AcSDKP encourages dermal fibroblasts and keratinocytes to proliferate and modulates hair growth.

Uses

N-Acetyl-Ser-Asp-Lys-Pro inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.

127103-11-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[2-[[2-[(2-acetamido-3-hydroxypropanoyl)amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names NAcSerDAspLysPro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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