127103-11-1 Usage
Skin Benifits
AcSDKP is an oligopeptide composed of acetyl-Ser-Asp-Lys-Pro. Found at low concentrations endogenously,
AcSDKP is produced from thymosin and inhibits the phosphorylation of Smad2, therefore
downsizing the expression of genes regulated by TGFβ. This mechanism mediates an antifibrotic effect
and a reduction in edema. AcSDKP is catabolized almost exclusively by angiotensin converting enzyme
I (ACEI), although ACEI-resistant analogs have been created. AcSDKP has been recognized as a potent
inducer of angiogenesis and an anti-inflammatory agent, also contributing to its anti-fibrotic effects. Its
cutaneous anti-aging effects have also been investigated. AcSDKP at a concentration of 10?7–10?11
stimulates the expression of proteins that strengthen tight junctions, including caludin-1, occluding,
and ZO-1.
In an ex vivo study, topical AcSDKP accelerated skin healing after UV irradiation. AcSDKP
also stimulates the proliferation of keratinocytes, fibroblasts, and epidermal basal layer cells. Topical
application of 10?5 M AcSDKP also inhibits aging of human skin explants by significantly increasing
epidermal thickness after only six days, increases collagen III along the papillary dermis and collagen
IV along the basal membrane, with a concomitant increase in GAGs, especially HA. This peptide also
modulates the growth of human hair in an ex vivo study. Treatment of normal human dermal fibroblast
cells with AcSDKP showed increased collagen I synthesis and SIRTI, improving skin structure and
increasing cell longevity.78 In one study, topically administered AcSDKP on an ex vivo skin-explant
model significantly increases epidermis thickness after only six days of treatment with 10?8 M AcSKDP.
In addition to upregulating the expression of collagen and fibronectin along the dermo-epithelial junction,
AcSKDP also increases GAG deposited in the ECM, especially hyaluronic acid. Lastly, AcSDKP
encourages dermal fibroblasts and keratinocytes to proliferate and modulates hair growth.
Uses
N-Acetyl-Ser-Asp-Lys-Pro inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.
Check Digit Verification of cas no
The CAS Registry Mumber 127103-11-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,1,0 and 3 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 127103-11:
(8*1)+(7*2)+(6*7)+(5*1)+(4*0)+(3*3)+(2*1)+(1*1)=81
81 % 10 = 1
So 127103-11-1 is a valid CAS Registry Number.
127103-11-1Relevant articles and documents
Synthesis and activity of NAcSerAspLysPro analogues on cellular interactions between T-cell and erythrocytes in rosette formation
Thierry,Papet,Saez-Servent,Plissonneau-Haumont,Potier,Lenfant
, p. 2122 - 2127 (2007/10/02)
Analogues of NAcSerAspLysPro (AcSDKP), a natural regulator of hematopoiesis isolated from fetal calf bone marrow, were synthesized. The biological activity of these molecules were evaluated in vitro in the rosette assay, which measures the interaction bet
