127107-29-3

Basic information

• Product Name: 3-AMINO-1-METHYLPYRAZOLE HYDROCHLORIDE
• Synonyms: 3-AMINO-1-METHYLPYRAZOLE HYDROCHLORIDE;1-Methyl-1H-pyrazol-3-amine hydrochloride;3-Amino-1-methyl-1H-pyrazole hydrochloride;1-methylpyrazol-3-amine:hydrochloride
• CAS NO: 127107-29-3
• Molecular Formula: C₄H₇N₃*ClH
• Molecular Weight: 133.57942
• EINECS: -0
• Mol File: 127107-29-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 203-208°C (decomposition)
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-AMINO-1-METHYLPYRAZOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-1-METHYLPYRAZOLE HYDROCHLORIDE(127107-29-3)
• EPA Substance Registry System: 3-AMINO-1-METHYLPYRAZOLE HYDROCHLORIDE(127107-29-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 127107-29-3(Hazardous Substances Data)

Upstream product

• 1904-31-0 methyl-1 amino-3 pyrazole 
• 60-34-4 methylhydrazine 
• 920-37-6 2-Chloroacrylonitrile 

Relevant articles and documents

Regiocontrolled synthesis of 3- and 5-aminopyrazoles, pyrazolo[3,4-d] pyrimidines, pyrazolo[3,4-b]pyridines and pyrazolo[3,4-b]quinolinones as MAPK inhibitors

Microwave irradiation of a hydrazine and 3-methoxyacrylonitrile, ethoxymethylenemalononitrile or ethyl acetoacetate provides rapid access to 3- or 5-substituted pyrazoles in excellent yield and with total regiocontrol in a process that can be switched from one regioisomer to the other by choice of conditions. Subsequent reaction, either by microwave-assisted hydrolysis and cyclocondensation with formamide, Hantzsch-type three-component reaction with an aldehyde and ketone, or by cyclocondensation with 2-nitrobenzaldehyde, provides the pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-b]pyridine or pyrazolo[3,4-b] quinolin-4-one framework, respectively, of inhibitors of mitogen-activated protein kinases.