127136-62-3Relevant articles and documents
Amino Acid Amide based Ionic Liquid as an Efficient Organo-Catalyst for Solvent-free Knoevenagel Condensation at Room Temperature
Burate, Pralhad A.,Javle, Balasaheb R.,Desale, Pranjal H.,Kinage, Anil K.
, p. 2368 - 2375 (2019)
Abstract: Ionic liquids of amino acid amide were synthesized and used as an efficient catalyst for solvent-free Knoevenagel condensation. Synthesized ionic liquids are an environmentally benign, inexpensive, metal free and plays the dual role of solvent as well as an efficient catalyst for Knoevenagel condensation. A wide range of aliphatic, aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. Additionally, the catalyst is easily separable and recyclable without loss of activity. Graphic Abstract: [Figure not available: see fulltext.].
Ionic liquid as catalyst and reaction medium - A simple, efficient and green procedure for Knoevenagel condensation of aliphatic and aromatic carbonyl compounds using a task-specific basic ionic liquid
Ranu, Brindaban C.,Jana, Ranjan
, p. 3767 - 3770 (2006)
The basic ionic liquid 1-butyl-3-methylimidazolium hydroxide, [bmIm]OH, efficiently catalyzes Knoevenagel condensation without requirement of any organic solvent. A wide range of aliphatic and aromatic aldehydes and ketones easily undergo condensations with diethyl malonate, malononitrile, ethyl cyanoacetate, malonic acid and ethyl acetoacetate. The reactions proceed at room temperature and are very fast (10-30 min). However, the most significant feature of this methodology is the condensation of aliphatic aldehyde with diethyl malonate, which is not very easy to achieve by conventional reagents, and was not addressed adequately in literature providing a general and convenient procedure. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Base-free Knoevenagel condensation catalyzed by copper metal surfaces
Schneider,Zeltner,Kr?nzlin,Grass,Stark
supporting information, p. 10695 - 10698 (2015/06/30)
For the first time Knoevenagel condensation has been catalyzed by elemental copper with unexpected activity and excellent isolated yields. Inexpensive, widely available copper powder was used to catalyze the condensation of cyanoacetate and benzaldehyde under mild conditions. To ensure general applicability, a wide variety of different substrates was successfully reacted.
A practical Knoevenagel condensation catalysed by imidazole
Heravi, Majid M.,Tehrani, Maryam H.,Bakhtiari, Khadijeh,Oskooie, Hossein A.
, p. 561 - 562 (2007/10/03)
The Knoevenagel condensation of aldehydes with active methylene compounds is easily carried out in dichloromethane using imidazole as an inexpensive catalyst. The olefinic products were obtained in high to excellent yields.
