127142-75-0Relevant academic research and scientific papers
Dual-action cephalosporins: Cephalosporin 3'-quaternary ammonium quinolones
Albrecht,Beskid,Christenson,Durkin,Fallat,Georgopapadakou,Keith,Konzelmann,Lipschitz,McGarry,Siebelist,Wei,Weigele,Yang
, p. 669 - 675 (1991)
When cephalosporins exert their biological activity by reacting with bacterial enzymes, opening of the β-lactam ring can lead to expulsion of the 3'-substituent. A series of cephalosporins was prepared in which antibacterial quinolones were linked to the
