Dual-action cephalosporins: Cephalosporin 3'-quaternary ammonium quinolones

DOI: 10.1021/jm00106a031

Source and publish data:

Journal of Medicinal Chemistry p. 669 - 675 (1991)

Update date:2022-08-02

Topics:

Authors:

Albrecht

Beskid Beskid

Christenson

Durkin Durkin

Fallat Fallat

Georgopapadakou

Keith Keith

Konzelmann

Lipschitz

McGarry McGarry

Siebelist

Wei Wei

Weigele Weigele

Yang Yang

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Article abstract of DOI:10.1021/jm00106a031

When cephalosporins exert their biological activity by reacting with bacterial enzymes, opening of the β-lactam ring can lead to expulsion of the 3'-substituent. A series of cephalosporins was prepared in which antibacterial quinolones were linked to the

Full text of DOI:10.1021/jm00106a031

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