Dual-action cephalosporins: Cephalosporin 3'-quaternary ammonium quinolones

Article abstract of DOI:10.1021/jm00106a031

When cephalosporins exert their biological activity by reacting with bacterial enzymes, opening of the β-lactam ring can lead to expulsion of the 3'-substituent. A series of cephalosporins was prepared in which antibacterial quinolones were linked to the