127154-22-7Relevant academic research and scientific papers
N-heterocyclic carbene catalyzed nucleophilic substitution reaction for construction of benzopyrones and benzofuranones
He, Jinmei,Zheng, Jiyue,Liu, Jian,She, Xuegong,Pan, Xinfu
, p. 4637 - 4640 (2006)
N-Heterocyclic carbene as an efficient organic catalyst was employed to catalyze an intramolecular nucleophilic substitution reaction. When R 2 was a phenyl group, the cyclization process underwent isomerization, leading to generation of benzofuranone.
PPh3-catalyzed ylide cyclization for the controllable synthesis of benzobicyclo[4.3.0] compounds: base effects and scope
Ye, Long-Wu,Han, Xun,Sun, Xiu-Li,Tang, Yong
, p. 1487 - 1493 (2008/09/19)
A catalytic intramolecular ylide annulation for the controllable construction of benzobicyclo[4.3.0] ring systems with three continuous stereogenic centers is developed in a single manipulation. In the presence of 20 mol % of triphenylphosphine, the react
1,4-dihydropyridine derivatives
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, (2008/06/13)
Compounds a formula (I) STR1 wherein the substituents and symbols have the meanings given in the specification, are new compounds with marked cardiovascular activity.
The Role of Substituents and Solvents in Promoting "Medium-Size" Ring-Chain Tautomerism
Jones, Paul R.,Jaglowski, Adam J.
, p. 3891 - 3896 (2007/10/02)
Two series of o-hydroxyalkoxybenzaldehydes have been examined by 1H and 13C NMR for their tendency to exhibit ring-chain tautomerism.All members of the diethylenoxy family exist as chain tautomers rather than partially or wholly as the 10-membered rings.The ethylenoxy compounds in solution are mixtures of chain and 7-membered ring tautomers in every case where a substituent is present on the aromatic ring ortho to the alkoxy group.Ring-chain equilibrium constants, determined by 1H NMR integration of methine and formyl peaks, varied as much as 100-fold with substituents and solvent.A good correlation is noted between percent ring tautomer and the size of the ortho substituent.A second substituent para to the alkoxy group enhances K considerably, even though K = 0 in cases where there is only a para substituent.
