127168-76-7

Basic information

• Product Name: 5-CHLOROISOINDOLINE HYDROCHLORIDE
• Synonyms: 5-CHLOROISOINDOLINE HYDROCHLORIDE;5-Chloroisoindoline;C90100;5-Chloro-2,3-dihydro-1H-isoindole
• CAS NO: 127168-76-7
• Molecular Formula: C₈H₈ClN
• Molecular Weight: 153.61
• Mol File: 127168-76-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 237℃
• Flash Point: 97℃
• Appearance: /
• Density: 1.214
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.60±0.20(Predicted)
• CAS DataBase Reference: 5-CHLOROISOINDOLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROISOINDOLINE HYDROCHLORIDE(127168-76-7)
• EPA Substance Registry System: 5-CHLOROISOINDOLINE HYDROCHLORIDE(127168-76-7)

Safety Data

• Hazardous Substances Data: 127168-76-7(Hazardous Substances Data)

Usage

General Description

5-Chloroisoindoline hydrochloride is a chemical compound with a molecular formula C8H9Cl2NO. It is a white to off-white crystalline powder that is used in the synthesis of pharmaceuticals and agrochemicals. 5-CHLOROISOINDOLINE HYDROCHLORIDE is a derivative of isoindoline, which is a building block in the production of various bioactive compounds. 5-Chloroisoindoline hydrochloride is a versatile intermediate in organic synthesis and can be used in the preparation of a wide range of compounds with biological and pharmacological activities. It is important to handle this chemical with care, as it may pose potential hazards if not properly managed.

InChI:InChI=1/C8H8ClN.ClH/c9-8-2-1-6-4-10-5-7(6)3-8;/h1-3,10H,4-5H2;1H

Upstream product

• 31684-14-7 1,2-bis(bromomethyl)-4-chlorobenzene 
• 615-60-1 4-chloro-1,2-dimethylbenzene 
• 127168-77-8 5-chloro-2-p-tosylisoindoline 
• 118-45-6 4-chlorophthalic anhydride 

Downstream Products

• 912999-79-2 5-chloro-2,3-dihydro-1H-isoindole hydrochloride 
• 913000-14-3 (2,4-bis-benzyloxy-5-isopropyl-phenyl)-(5-chloro-1,3-dihydro-isoindol-2-yl)-methanone 
• 1258507-84-4 C₁₉H₁₇ClF₃NO₄S 
• 1221962-74-8 ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate 

Relevant articles and documents

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors

A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2-250 nM) with selectivity over DPP-II, DPP8, and FAP enzymes. Selected compounds 8c and 11a showed in vivo plasma DPP-IV inhibition after oral administration in Wistar rats.

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

PHARMACEUTICAL COMBINATIONS

The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1- 5 hydrocarbyloxy; R4 is selected from hydrogen; a group -(O)n-R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The combinations have activity as Hsp90 inhibitors.