118-45-6Relevant academic research and scientific papers
Preparation method, preparation device and intermediate of 4 -chlorophthalic anhydride
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Paragraph 0084; 0100-0108; 0115-0117; 0124-0126; 0133; ..., (2021/10/27)
The invention discloses a preparation method of 4 -chlorophthalic anhydride, a preparation device and an intermediate. The preparation method comprises the following steps: 2, 3 - dichloro maleic anhydride and 2 - chlorine -1, 3 - butadiene takes place cyclization reaction to obtain 1, 2 and 4 - trichloroacetic anhydride. Reaction of the 1, 2 and 4 - trichloroalternative dihydrophthalic anhydride in the removal HCl results in 4 -chlorophthalic anhydride. The chlorination reaction of maleic anhydride and thionyl chloride under the conditions of pyridine catalysts gives the 2, 3 -dichloromaleic anhydride. By adopting 2, 3 -dichloromaleic anhydride and 2 - chlorine -1, 3 - butadiene takes place D-A cyclization reaction, HCl-chlorophthalic anhydride is synthesized with high selectivity, and the 4 - 4 -chlorophthalic anhydride process disclosed by the invention realizes continuous production.
A double-(mild imide) preparation method (by machine translation)
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Paragraph 0041; 0042, (2018/07/07)
The invention relates to a double-(mild imide) of the preparation method, the phthalic anhydride is dissolved in water, into the chlorine gas, heating the reaction system to 25 - 80 °C, sustained reaction 8 - 12 hours, met for preparing double-(mild imide) the technological requirements of mild phthalic anhydride; the prepared mild phthalic anhydride and diamine compound in presence of solvent, in the 40 - 300 °C lower, vacuum to - 0.02 - - 0.08 mpa reaction 8 - 16 hours, the reaction after the end of the, is filtered by the filter cake, the filter cake washing in boiling water, filtering to obtain the double-(mild imide). The invention producing polyimide precursor double (mild imide) of the method is simple and convenient, the reaction is carried out under negative pressure, the safety is high, using only the solvent, without using a catalyst and a dehydrating agent, and after treatment is simple, and is suitable for industrial production, the production cost is low, the product quality is good. (by machine translation)
PROCESS FOR THE PREPARATION OF ORGANIC HALIDES
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Paragraph 00146, (2017/08/01)
The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.
Pd-Catalyzed Decarbonylative Cross-Couplings of Aroyl Chlorides
Malapit, Christian A.,Ichiishi, Naoko,Sanford, Melanie S.
supporting information, p. 4142 - 4145 (2017/08/15)
This report describes a method for Pd-catalyzed decarbonylative cross-coupling that enables the conversion of carboxylic acid derivatives to biaryls, aryl amines, aryl ethers, aryl sulfides, aryl boronate esters, and trifluoromethylated arenes. The success of this transformation leverages the Pd0/Brettphos-catalyzed decarbonylative chlorination of aroyl chlorides, which can then participate in diverse cross-coupling reactions in situ using the same Pd catalyst.
ALLOSTERIC PROTEIN KINASE MODULATORS
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Page/Page column 45, (2012/03/10)
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
Dual fluorescent N-Aryl-2,3-naphthalimides: Applications in ratiometric DNA detection and white organic light-emitting devices
Nandhikonda, Premchendar,Heagy, Michael D.
supporting information; experimental part, p. 4796 - 4799 (2011/01/03)
A ten element matrix of 5- and 6-substituted-(2,3)-naphthalimides was prepared for the appropriate placement of substituents necessary to promote dual fluorescence (DF). As prescribed by our balanced seesaw photophysical model this matrix yielded nine new DF dyes out of a possible ten compounds. From this set of nine DF dyes, 4-fluoronaphthalic amide (37) was selected as a probe for ratiometric detection of DNA and demonstration of panchromatic emission.
ALLOSTERIC PROTEIN KINASE MODULATORS
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Page/Page column 93-94, (2010/04/30)
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
Method of making halophthalic acids and halophthalic anhydrides
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Page/Page column 9, (2008/06/13)
A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition a method for the preparation of halophthalic anhydride is also disclosed.
Sarcosine based indandione hGlyT1 inhibitors
Thomson, Christopher G.,Duncan, Karen,Fletcher, Stephen R.,Huscroft, Ian T.,Pillai, Gopalan,Raubo, Piotr,Smith, Alison J.,Stead, Darren
, p. 1388 - 1391 (2007/10/03)
A series of sarcosine based indandione hGlyT1 inhibitors has been developed. Optimization of substitution around the indandione and sarcosine moieties has led to highly potent inhibitors at hGlyT1, which show selectivity over a number of other receptors.
PREPARATION OF SUBSTITUTED PHTHALIC ANHYDRIDE, ESPECIALLY 4-CHLOROPHTALIC ANHYDRIDE
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Page 6-7, (2008/06/13)
A method for the synthesis of substituted phthalic anhydrides (IV) wherein R' is a halogen, aromatic or aliphatic group comprising 1-18 carbons, hydrogen or nitro group is the transimidation between a substituted N-alkyl phthalimide (V) wherein R is an alkyl having from 1 to 18 carbons, and a substituted tetrahydrophthalic anhydride (VI): The by product of this reaction, a substituted N-alkyl tetrahydrophthalimide (VII), may be converted by aromatization to the substituted N-alkyl phthalimide (V).
