118-45-6Relevant articles and documents
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Weiler-Feilchenfeld,H.,Solomonovici,A.
, p. 869 - 871 (1971)
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Preparation method, preparation device and intermediate of 4 -chlorophthalic anhydride
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Paragraph 0084; 0100-0108; 0115-0117; 0124-0126; 0133; ..., (2021/10/27)
The invention discloses a preparation method of 4 -chlorophthalic anhydride, a preparation device and an intermediate. The preparation method comprises the following steps: 2, 3 - dichloro maleic anhydride and 2 - chlorine -1, 3 - butadiene takes place cyclization reaction to obtain 1, 2 and 4 - trichloroacetic anhydride. Reaction of the 1, 2 and 4 - trichloroalternative dihydrophthalic anhydride in the removal HCl results in 4 -chlorophthalic anhydride. The chlorination reaction of maleic anhydride and thionyl chloride under the conditions of pyridine catalysts gives the 2, 3 -dichloromaleic anhydride. By adopting 2, 3 -dichloromaleic anhydride and 2 - chlorine -1, 3 - butadiene takes place D-A cyclization reaction, HCl-chlorophthalic anhydride is synthesized with high selectivity, and the 4 - 4 -chlorophthalic anhydride process disclosed by the invention realizes continuous production.
Pd-Catalyzed Decarbonylative Cross-Couplings of Aroyl Chlorides
Malapit, Christian A.,Ichiishi, Naoko,Sanford, Melanie S.
supporting information, p. 4142 - 4145 (2017/08/15)
This report describes a method for Pd-catalyzed decarbonylative cross-coupling that enables the conversion of carboxylic acid derivatives to biaryls, aryl amines, aryl ethers, aryl sulfides, aryl boronate esters, and trifluoromethylated arenes. The success of this transformation leverages the Pd0/Brettphos-catalyzed decarbonylative chlorination of aroyl chlorides, which can then participate in diverse cross-coupling reactions in situ using the same Pd catalyst.
ALLOSTERIC PROTEIN KINASE MODULATORS
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Page/Page column 45, (2012/03/10)
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.