127178-03-4Relevant academic research and scientific papers
POLYBASIC AMINES. I. SYNTHESIS OF N-CARBOXYMETHYL- AND N-(β-CARBOXYETHYL)-N-(β-AMINOETHYL)PIPERAZINES
Zagidullin, R. N.
, p. 1986 - 1989 (2007/10/02)
The hydrolysis of N-(β-cyanoethyl)-N'-(β-salicylideneaminomethyl)piperzine in the presence of hydrochloric acid leads to the formation of N-(β-carboxyethyl)-N'-(β-aminoethyl)piperazine, from which N-(β-carboxyethyl)-N'-(biscarboxymethyl-aminoethyl)piperazine is produced by the action of monochloroacetic acid.Under analogous conditions the hydrolysis of N-carboxymethyl-N'-(β-salicylideneaminoethyl)piperazine with concentrated hydrochloric acid followed by cyanoethylation of the product and hydrolysis gave N-carboxymethyl-N'-(di-β-carboxyethylaminoethyl)piperazine.
