87980-97-0

Usage

Derivative of

Piperazine

Classification

Amino acid

Common uses

Synthesis of peptides, building block in organic chemistry

Potential applications

Pharmaceutical industry (medicinal chemistry), drug design and development

Versatility

Various potential uses in the pharmaceutical and chemical industries

Upstream product

• 93968-73-1 2-(((2-(piperazin-1-yl)ethyl)imino)methyl)phenol 
• 127178-03-4 N-(β-carboxyethyl)-N'-(β-salicylideneaminoethyl)-piperazine 
• 127178-04-5 N-carboxymethyl-N'-(β-aminoethyl)piperazine trihydrochloride 

Relevant academic research and scientific papers

NOVEL MULTIMERIC MOLECULES, A PROCESS FOR PREPARING THE SAME AND THE USE THEREOF FOR MANUFACTURING MEDICINAL DRUGS

The invention relates to a compound of the formula (I): in which k and j are independently 0 or 1, Y is a macrocycle in which the cycle includes 9 to 36 carbon atoms and is functionalised by three amino functions and by a chain for attaching the spacer arm Z via an X bond, Rc is a binding pattern with a receptor of the TNF superfamily, X is a chemical function for binding the Y group to the space arm, and Z is a bi-, tri- or tetra-functional spacer arm.

NOVEL MULTIMERIC CD40 LIGANDS, METHOD FOR PREPARING SAME AND USE THEREOF FOR PREPARING DRUGS

The invention concerns a compound of formula (I), wherein Y represents a macrocycle whereof the cycle comprises 9 to 36 atoms, and is functionalized by three amine or COOH functions; Rc represents a group of formula H—Xa—Xb—Xc—Xd—Xe—(Xf)i—, wherein i represents 0 or 1, Xn is in particular selected among lysine, arginine, ornithine residues, Xb is in particular selected among glycine, asparagine, L-proline or D-proline residues, Xc et Xd are in particular selected among tyrosine, phenylalanine or 3-nitrotyrosine residues, Xe et Xf are in particular selected among the following amino acid residues: NH2—(CH2)n—COOH, n ranging from 1 to 10 or NH2—(CH2—CH2—O)m—CH2CH2COOH, m ranging from 3 to 6, provided that one at least of the amino acid residues Xa, Xb, Xc and Xd is different from the corresponding amino acid in the sequence of the natural CD40 143Lys-Gly-Tyr-Tyr146 fragment

POLYBASIC AMINES. I. SYNTHESIS OF N-CARBOXYMETHYL- AND N-(β-CARBOXYETHYL)-N-(β-AMINOETHYL)PIPERAZINES

The hydrolysis of N-(β-cyanoethyl)-N'-(β-salicylideneaminomethyl)piperzine in the presence of hydrochloric acid leads to the formation of N-(β-carboxyethyl)-N'-(β-aminoethyl)piperazine, from which N-(β-carboxyethyl)-N'-(biscarboxymethyl-aminoethyl)piperazine is produced by the action of monochloroacetic acid.Under analogous conditions the hydrolysis of N-carboxymethyl-N'-(β-salicylideneaminoethyl)piperazine with concentrated hydrochloric acid followed by cyanoethylation of the product and hydrolysis gave N-carboxymethyl-N'-(di-β-carboxyethylaminoethyl)piperazine.

Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives

Tricyclic antidepressant drug (e.g., imipramine, desipramine, amitriptyline, or nortriptyline) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining such drug. The immunogens comprise the drug coupled at its 2'-position to an immunogenic carrier material. Similarly, the labeled conjugates and synthetic intermediates are 2'-derivatives of the drug or a precursor thereof. The antibodies and labeled reagents are particularly useful in certain homogeneous nonradioisotopic immunoassays for measuring tricyclic antidepressant drugs in biological fluids such as serum.