1272012-51-7Relevant articles and documents
Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3- benzazocine and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine
Coe, Jotham W.,Brooks, Paige R.,Vetelino, Michael G.,Bashore, Crystal G.,Bianco, Krista,Flick, Andrew C.
, p. 953 - 954 (2011/03/18)
Concise syntheses of 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine (12) and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine (18) are described and involve an intramolecular Friedel-Crafts alkylation and an intramolecular Heck cyclization as their respec