127218-58-0

Usage

Common Uses

Solvent
Stabilizer
Intermediate in industrial processes

Color

Colorless liquid

Odor

Mild, ether-like

Solubility

Soluble in water, alcohol, and other organic solvents

Chemical Properties

Ability to form stable complexes with metal ions

Applications

Metal extraction and purification processes
Production of pharmaceuticals
Production of agrochemicals
Production of other fine chemicals
Personal care and cleaning products

Environmental Impact

Toxic to aquatic organisms

Health Risks

Potential for skin and eye irritation in humans

Handling and Disposal

Requires careful management due to environmental and health risks

Upstream product

• 102147-75-1 2,2-dimethyl-5-(2'-hydroxyethyl)-1,3-dioxane 
• 98-59-9 p-toluenesulfonyl chloride 
• 113999-09-0 5-(2-propenyl)-2,2-dimethyl-1,3-dioxane 
• 7459-46-3 triethyl 1,1,2-ethanetricarboxylate 

Downstream Products

• 127205-15-6 2-amino-6-benzyloxy-9-<2'-(2,2-dimethyl-1,3-dioxan-5-yl)-ethyl>-9H-purine 
• 127205-16-7 2-amino-6-benzyloxy-7-<2'-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl>-7H-purine 
• 1296137-03-5 (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-pyrrol-2-yl)acrylamide 
• 1296137-04-6 (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-pyrazol-4-yl)acrylamide 
• 1296137-05-7 (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-imidazol-4-yl)acrylamide 
• 1296137-06-8 (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide 
• 127205-22-5 7-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine 
• 39809-25-1 Penciclovir 

Relevant academic research and scientific papers

Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents

NAmPRTase (PBEF/Visfatin) plays a pivotal role in the salvage pathway of NAD+ biosynthesis. NAmPRTase has been an attractive target for anti-cancer agents that induce apoptosis of tumor cells via a declining plasma NAD+ level. In this report, a series of structural analogs of FK866 (1), a known NAmPRTase inhibitor, was synthesized and tested for inhibitory activities against the proliferation of cancer cells and human NAmPRTase. Among them, compound 7 showed similar anti-cancer and enzyme inhibitory activities to compound 1. Further investigation of compound 7 with X-ray analysis revealed a co-crystal structure in complex with human NAmPRTase, suggesting that Asp219 in the active site of the enzyme could contribute to an additional interaction with the pyrrole nitrogen of compound 7.

Carba-acyclonucleoside antiherpetic agents

Ganciclovir 2 and 2'-carba-ganciclovir 5a are anti-viral agents differing structurally only in the replacement of an oxygen by a methylene group and yet expressing their biological properties along mechanistically independent pathways. Methoxy, hydroxy an